SPATIAL WORKING MEMORY IN RATS - EFFECTS OF MONO-AMINERGIC ANTAGONISTS
SPATIAL WORKING MEMORY IN RATS - EFFECTS OF MONO-AMINERGIC ANTAGONISTS
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DOI：
10.1016/0091-3057(83)90242-3
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
RUSH, JR
中科院分区：
文献类型：
--
作者：
BEATTY, WW;RUSH, JR
为了评估单胺能神经递质去甲肾上腺素，多巴胺和5-羟色胺在空间工作记忆的维持中的可能参与，在8臂迷宫中完成前4个选择后0或2小时用拮抗剂处理大鼠。选择4后2小时给药氟哌啶醇（0.25-1.0 mg/kg）会对前4个选择后5小时进行的保留测试的表现产生轻微但一致的损害。就所犯错误的类型而言，这种缺陷与自然遗忘非常相似。在选择4或前4个选择前3 h后0 h或3 h给予相同剂量的氟哌啶醇不影响保留。用普萘洛尔（10-20 mg/kg）、酚妥拉明（5-20 mg/kg）或麦角新碱（5-15 mg/kg）治疗不会损害空间记忆，无论这些药物在治疗期间何时注射。显然，多巴胺能神经元系统在维持正常的空间工作记忆中是重要的。
To assess the possible involvement of the monoaminergic neurotransmitters norepinephrine, dopamine and serotonin in the maintenance of spatial working memory rats were treated with antagonists 0 or 2 h after completing the first 4 choices in an 8-arm maze. Haloperidol (0.25-1.0 mg/kg) when administered 2 h after choice 4 produced a small but consistent impairment in performance on retention tests given 5 h after the first 4 choices. This deficit closely resembled natural forgetting in terms of the type of errors committed. Haloperidol in the same doses given 0 h after choice 4 or 3 h before the first 4 choices did not affect retention. Treatment with propranolol (10-20 mg/kg), phentolamine (5-20 mg/kg) or methysergide (5-15 mg/kg) did not impair spatial memory, regardless of when these drugs were injected within the session. Evidently, dopaminergic neuronal systems are important in the maintenance of normal spatial working memory.