Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.
Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.
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DOI：
10.1016/j.dnarep.2015.11.021
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发表时间：
2016-02
期刊：
影响因子：
3.8
通讯作者：
Li GM
中科院分区：
文献类型：
--
作者：
Li F;Ortega J;Gu L;Li GM
DNA错配修复（MMR）通过纠正DNA复制相关的错配，调节DNA损伤诱导的细胞周期检查点和调节同源重组来保护基因组的完整性。MMR功能的丧失导致癌症的发展。本文综述了MMR是如何在染色质的背景下进行的，以及染色质组织/压实，表观遗传机制和MMR蛋白的翻译后修饰如何影响和调节真核细胞中的MMR。
DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.