Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1R,2R)-2-(Dimethylamino)- 1,2-diphenylethanol
Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1R,2R)-2-(Dimethylamino)- 1,2-diphenylethanol
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DOI：
10.1002/adsc.200505157
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发表时间：
2005-10
影响因子：
5.4
通讯作者：
M. Yamashita;Ken‐ichi Yamada;K. Tomioka
中科院分区：
文献类型：
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作者：
M. Yamashita;Ken‐ichi Yamada;K. Tomioka
以三氟化锌和(1R，2R)-2-(二甲氨基)-1，2-二苯乙醇为催化剂，在甲苯中催化醛与端炔的不对称炔化反应，得到对映体过量高达98%的醇。
Catalytic asymmetric alkynylation of aldehydes with terminal alkynes was catalyzed by zinc triflate and (1R,2R)-2-(dimethylamino)-1,2-diphenylethanol in toluene to give the corresponding alcohols with high enantiomeric excess up to 98% in good yields.