Does reproduction cause oxidative stress? An open question
Does reproduction cause oxidative stress? An open question
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DOI：
10.1016/j.tree.2013.01.015
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发表时间：
2013-06-01
影响因子：
16.8
通讯作者：
Monaghan, Pat
中科院分区：
文献类型：
--
作者：
Metcalfe, Neil B.;Monaghan, Pat
最近，人们对氧化应激作为生命史权衡的潜在机制的可能作用非常感兴趣，特别是在生殖成本方面。最近的几篇论文没有发现生殖增加氧化损伤的证据，因此质疑了氧化损伤调节生殖-寿命权衡的假设基础。然而，我们在这里提出，没有预测的关系可能是由于所有已发表的经验研究设计中的一个基本问题，即未能操纵生殖努力。最后，我们提出了一些实验方法，这些方法可能会对这一假设进行更确凿的检验。
There has been substantial recent interest in the possible role of oxidative stress as a mechanism underlying life-history trade-offs, particularly with regard to reproductive costs. Several recent papers have found no evidence that reproduction increases oxidative damage and so have questioned the basis of the hypothesis that oxidative damage mediates the reproduction-lifespan trade-off. However, we suggest here that the absence of the predicted relationships could be due to a fundamental problem in the design of all of the published empirical studies, namely a failure to manipulate reproductive effort. We conclude by suggesting experimental approaches that might provide a more conclusive test of the hypothesis.