Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.
Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.
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使用氟喹诺酮、红霉素、皮质类固醇和西维来司他的组合成功治疗了严重的军团病。
DOI：
10.2169/internalmedicine.47.0677
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发表时间：
2008
影响因子：
1.2
通讯作者：
S. Kohno
中科院分区：
文献类型：
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作者：
H. Kakeya;Naomi Ehara;K. Fukushima;M. Seki;K. Izumikawa;Yoshihiro Yamamoto;K. Yanagihara;A. Saito;S. Kohno
患者是一名67岁男性，患有糖尿病，入院前几天曾去过温泉浴场。军团菌肺炎的诊断是通过尿抗原测定进行的。开始静脉注射帕珠沙星和口服克拉霉素。然而，尽管进行了这些治疗，他还是患上了急性呼吸窘迫综合征（ARDS）。他接受了静脉注射帕珠沙星和红霉素、皮质类固醇和西维来司他的组合治疗，为期两周。随后他就被成功康复。结果表明，对于合并 ARDS 的严重军团菌肺炎患者，除了联合使用适当的抗军团菌抗生素外，还应考虑使用皮质类固醇和西维来司他进行治疗。
The patient was a 67-year-old man with diabetes mellitus who had been to a hot spring spa a few days before his admission. The diagnosis of Legionella pneumonia was made using a urinary antigen assay. Intravenous pazufloxacin and oral clarithromycin were started. However, despite these treatments, he developed acute respiratory distress syndrome (ARDS). He was administered the combination of intravenous pazufloxacin and erythromycin, corticosteroid, and sivelestat for two weeks. Then he was successfully recovered. The outcome suggests that treatment with corticosteroid and sivelestat, in addition to a combination of appropriate anti-Legionella antibiotics, should be considered for patients with severe Legionella pneumonia with ARDS.
约翰·霍普金斯大学/德克萨斯大学/犹他大学（美国）
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Inoue, Y;Seiyama, A;Sugimoto, H
通讯作者：
Sugimoto, H