Tests for DNA and chromosomal damage induced by nuclear magnetic resonance imaging.
Tests for DNA and chromosomal damage induced by nuclear magnetic resonance imaging.
复制标题
核磁共振成像诱导的 DNA 和染色体损伤测试。
作者：
S. Wolff;L. Crooks;P. Brown;R. Howard;R. Painter
将培养的中国仓鼠卵巢 (CHO) 细胞暴露在核磁共振 (NMR) 成像设备中，置于强磁场、脉冲场梯度和射频发射下。即使暴露约 14 小时后也没有诱发染色体畸变。暴露于低（平均 7.2 mW）或高（平均 61.2 mW）射频功率四小时均不会诱导姐妹染色单体交换。当 HeLa 细胞暴露于 61.2 mW 的平均射频功率 16 小时时，没有检测到 DNA 合成受到抑制。这些数据表明，用于 NMR 成像的条件不会造成可通过任何这些方法检测到的遗传损伤。
Chinese hamster ovary (CHO) cells in culture were exposed in a nuclear magnetic resonance (NMR) imaging apparatus to a strong magnetic field, pulsed field gradients, and radio frequency emissions. No chromosomal aberrations were induced even after an exposure of approximately 14 hours. No sister chromatid exchanges were induced by four-hour exposures to either low (average 7.2 mW) or high (average 61.2 mW) radio frequency power. When HeLa cells were exposed for 16 hours to an average radio frequency power of 61.2 mW, no inhibition of DNA synthesis was detectable. These data indicate that the conditions used for NMR imaging do not cause genetic damage which is detectable by any of these methods.