Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression.
Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression.
复制标题
行为抑郁的绝经后食蟹猴的海马体积。
DOI：
10.1097/gme.0b013e3181fcb47e
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Shively,CarolA
中科院分区：
文献类型：
--
作者：
Willard,StephanieL;Daunais,JamesB;Cline,JMark;Shively,CarolA
目的：磁共振成像（MRI）研究报告抑郁症海马（HC）体积减少。尽管观察到海马的功能异质性和卵巢类固醇的影响，很少有研究报告区域体积改变或控制月经周期阶段。使用体外方法，我们最近观察到减少前HC体积在抗抑郁药的幼稚，卵巢完整，行为抑郁的成年雌性猴子。本研究的目的是确认这些结果在体内，并检查是否缺乏卵巢类固醇影响抑郁症和HC volume.Methods之间的关系：MRI被用来测量整个，前部和后部HC体积在一个匹配的抗抑郁药，天真的，手术绝经后的成年女性食蟹猴的行为抑郁症（6抑郁症，6 nondepressed）为特征的样本。获取高分辨率结构MRI，手动分割HC感兴趣区域。HC体积进行了归一化全脑体积analysis.Results：类似于以前的体外研究，HC体积测量在体内与抑郁症。与之前对卵巢完整雌性猴的研究相反，与非抑郁的手术绝经后雌性猴相比，抑郁症患者左侧和右侧海马的整体、前部和后部体积显着较小。结论：这些发现证实并扩展了之前的观察结果行为抑郁雌性猴的HC体积较小，并表明卵巢类固醇可能在抑郁症的HC保护中发挥作用。进一步研究卵巢功能对抑郁症和HC体积之间关系的潜在调节作用是必要的。
Objective:Magnetic resonance imaging (MRI) studies report hippocampal (HC) volume reductions in depression. Despite observations of functional heterogeneity and ovarian steroid influence in the hippocampus, few studies report regional volume alterations or control for menstrual cycle phase. Using in vitro methods, we recently observed reduced anterior HC volume in antidepressant-naive, ovarian-intact, behaviorally depressed adult female monkeys. The purpose of this study was to confirm these findings in vivo and examine whether lack of ovarian steroids affects the relationship between depression and HC volume.Methods:MRI was used to measure whole, anterior, and posterior HC volumes in a matched sample of antidepressant-naive, surgically postmenopausal adult female cynomolgus macaques characterized for behavioral depression (six depressed, six nondepressed). High-resolution structural MRIs were acquired, and HC regions of interest were manually segmented. HC volumes were normalized to whole brain volumes before analysis.Results:Similar to the previous in vitro study, HC volume measured in vivo was associated with depression. In contrast to the previous study of ovarian-intact female monkeys, whole, anterior, and posterior volumes of both the left and right hippocampi were significantly smaller in depressed compared with nondepressed surgically postmenopausal female monkeys.Conclusions:These findings confirm and extend previous observations of smaller HC volumes in behaviorally depressed female monkeys and suggest a possible role for ovarian steroids in HC protection in depression. Further studies of the potential modulating effects of ovarian function on the relationship between depression and HC volume are warranted.