Chaperones and slow death - a recipe for tumor immunotherapy
Chaperones and slow death - a recipe for tumor immunotherapy
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DOI：
10.1016/j.tibtech.2004.12.011
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发表时间：
2005-02-01
影响因子：
17.3
通讯作者：
Calderwood, SK
中科院分区：
文献类型：
--
作者：
Calderwood, SK
在最近一篇令人兴奋的论文中，Richard Vile及其同事描述了一种基于在炎症环境中杀死正常细胞群体的肿瘤免疫治疗新方法。这种方法建立在最近的研究基础上，这些研究表明分子伴侣Hsp70可以在肿瘤抗原呈递过程中的多个阶段起作用，以增强CD8（+）T淋巴细胞介导的免疫的产生，并导致原发性和转移性肿瘤的消退。
In an exciting recent paper Richard Vile and coworkers describe a novel approach to tumor immunotherapy based on the killing of a population of normal cells within an inflammatory environment. This approach builds on recent studies showing that the molecular chaperone Hsp70 can act at multiple stages during tumor antigen presentation to enhance the generation of CD8(+) T lymphocyte-mediated immunity and lead to regression of primary and metastatic tumors.