Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence.
Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence.
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DOI：
10.3389/fneur.2012.00013
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发表时间：
2012
影响因子：
3.4
通讯作者：
Baker FC
中科院分区：
文献类型：
--
作者：
Colrain IM;Padilla ML;Baker FC
在睡眠期间呈现的刺激可以产生被称为K复合波的诱发EEG δ波。当大量的皮层细胞以同步的方式爆发时，这些反应就会发生。大幅度同步头皮反应要求CNS包含大量与高功能性白色物质通路互连的健康神经元。诱发的K波群的P2、N550和P900成分是正常健康脑老化的敏感指标，其振幅随年龄增长而降低。N550和P900的振幅也减少了最近脱毒的酗酒者，最显着超过额部头皮区域。本研究验证了K波相关诱发电位成分的振幅随戒断时间延长而增加的假设。15名酗酒者（12名男性）被研究了两次，间隔12个月，在此期间，他们每月都会打电话。受试者在首次研究时的年龄在38至60岁之间。他们平均有29.3 ± 6.7年的饮酒史，在最初的测试中已经戒酒54到405天。在EEG中识别诱发的K复合体，并取平均值以测量P2、N550和P900峰。从7个头皮部位（FP1、FP2、Fz、FCz、Cz、CPz和Pz）收集数据。戒断12个月后，N550和P900振幅显著升高，15名受试者中有12名至少改善了5 μV。N550和P900也表现出高度显着的网站夜间相互作用，最大的增幅发生在前额和额叶网站。这些数据表明，睡眠诱发反应可以提供一个敏感的标记，从酒精戒断的大脑恢复。
Stimuli presented during sleep can produce an evoked EEG delta wave referred to as a K-complex. These responses occur when large numbers of cortical cells burst fire in a synchronized manner. Large amplitude synchronized scalp responses require that the CNS contain large numbers of healthy neurons that are interconnected with highly functional white matter pathways. The P2, N550, and P900 components of the evoked K-complex are sensitive measures of normal healthy brain aging, showing a decrease in amplitude with age. N550 and P900 amplitudes are also reduced in recently detoxified alcoholics, most dramatically over frontal scalp regions. The present study tested the hypothesis that the amplitude of K-complex related evoked potential components would increase with prolonged abstinence. Fifteen alcoholics (12 men) were studied twice, separated by a 12 month period, during which time they were followed with monthly phone calls. Subjects were aged between 38 and 60 years at their first study. They had on average a 29.3 ± 6.7 year drinking history and had been abstinent for between 54 and 405 days at initial testing. Evoked K-complexes were identified in the EEG and averaged to enable measurement of the P2, N550 and P900 peaks. Data were collected from seven scalp sites (FP1, FP2, Fz, FCz, Cz, CPz, and Pz). N550 and P900 amplitudes were significantly higher after 12 months of abstinence and an improvement of at least 5 μV occurred in 12 of the 15 subjects. N550 and P900 also showed highly significant site by night interactions with the largest increases occurring over prefrontal and frontal sites. The data indicate that the sleep evoked response may provide a sensitive marker of brain recovery with abstinence from alcohol.