MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
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DOI：
10.1016/s0197-4580(01)00271-8
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发表时间：
2001-09-01
影响因子：
4.2
通讯作者：
deToledo-Morrell, L
中科院分区：
文献类型：
--
作者：
Dickerson, BC;Goncharova, I;deToledo-Morrell, L
有了高分辨率的定量磁共振成像(NM)技术，现在可以在体内检查大脑解剖的变化，并确定阿尔茨海默病(AD)早期受影响的区域。在这项研究中，我们比较了健康的老年对照组、临床上有认知主诉但不符合痴呆症(非痴呆)标准的患者和非常轻微的AD患者的NM来源的内嗅觉和海马体体积。两组患者在内嗅觉体积上与对照组有显著差异，但彼此之间没有显著差异；相反，他们彼此之间以及与对照组之间的海马体体积不同，轻度AD患者表现出最严重的萎缩。对23/28名非痴呆症患者的随访临床评估表明，12/23名患者在基线MRI检查后12-77个月内转为AD。根据内嗅觉的体积可以最好地区分转换型和非转换型，但不能根据海马体体积来区分。这些数据表明，尽管EC和海马结构都在显性痴呆发病前退化，但EC。成交量是一个更好的转化率预测指标。(C)2001 Elsevier Science Inc.保留所有权利。
With high resolution, quantitative magnetic resonance imaging (NM) techniques, it is now possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In this study, we compared NM-derived entorhinal and hippocampal volume in healthy elderly controls, patients who presented at the clinic with cognitive complaints, but did not meet criteria for dementia (non-demented), and patients with very mild AD. The two patient groups differed significantly from controls in entorhinal volume, but not from each other; in contrast, they differed from each other, as well as from controls, in hippocampal volume, with the mild AD cases showing the greatest atrophy. Follow-up clinical evaluations available on 23/28 non-demented patients indicated that 12/23 had converted to AD within 12-77 months from the baseline MRI examination. Converters could be best differentiated from non-converters on the basis of entorhinal, but not hippocampal volume. These data suggest that although both the EC and hippocampal formation degenerate before the onset of overt dementia, EC. volume is a better predictor of conversion. (C) 2001 Elsevier Science Inc. All rights reserved.