Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm.
Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm.
复制标题
重组人血清素转运蛋白连接启动子区多态性与恒河猴在分离范式中的行为之间的关联。
DOI：
10.1017/s095457940700048x
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发表时间：
2007
影响因子：
3.3
通讯作者：
Barr,ChristinaS
中科院分区：
文献类型：
--
作者：
Spinelli,Simona;Schwandt,MelanieL;Lindell,StephenG;Newman,TimothyK;Heilig,Markus;Suomi,StephenJ;Higley,JDee;Goldman,David;Barr,ChristinaS
人类研究表明，5-羟色胺转运体基因启动子区域的可变长度多态性与易患焦虑和抑郁症之间存在关联。相对于长（l）等位基因，短（s）等位基因增加了暴露于压力生活事件的个体患抑郁症的风险。人类变异的直系同源物存在于恒河猴中，并允许在暴露于压力的动物中进行研究。在这里，我们使用了一个建立的早期生活压力暴露模型，其中恒河猴在没有成年人的情况下在一组同龄人中长大（仅同龄人饲养[PR]），或与他们的母亲一起长大。在6个月大时，动物连续4周进行4天的社会分离，中间有3天的团聚。在分离的急性期（第1天）和慢性期（第2-4天）收集数据。行为因素分别提取的每个阶段的分离。对于急性分离，产生的行为因素是绝望和行为病理学，而对于慢性阶段，绝望、激动和行为病理学。在社会分离的两个阶段，PR 1/s动物更有可能表现出病理行为，而PR 1/1猴子显示出更高水平的绝望相比，其他三组。这些研究结果表明，早期的压力影响的行为反应分离不同的功能重组人5-羟色胺转运蛋白连锁多态性重复基因型，并建议运营商的s等位基因不仅更焦虑，但也可能更容易发展中国家的行为病理在面对慢性逆境。
Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression. Relative to the long (l) allele, the short (s) allele increases the risk of developing depression in individuals exposed to stressful life events. An orthologue of the human variant is present in rhesus macaques and allows for studies in animals exposed to stress. Here, we used an established model of early life stress exposure, in which rhesus macaques are raised without adults in a group of peers (peer-only reared [PR]), or with their mothers. At 6 months of age, animals were subjected to 4-day long social separations for 4 consecutive weeks, with 3 days of reunion in between. Data were collected during both the acute (Day 1) and chronic phases (Days 2–4) of separation. Behavioral factors were separately extracted for each phase of separation. For acute separation, the behavioral factors generated were despair and behavioral pathology and, for the chronic phase despair, agitation, and behavioral pathology. During both phases of social separation, PR l/s animals were more likely to exhibit pathological behaviors, whereas PR l/l monkeys show higher levels of despair compared to the other three groups. These findings indicate that early stress affects the behavioral response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype and suggest that carriers of the s allele are not only more anxious but may also be more vulnerable to developing behavioral pathology in the face of chronic adversity.