Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease.
Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease.
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DOI：
10.2147/copd.s30399
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发表时间：
2012
影响因子：
2.8
通讯作者：
Nagase T
中科院分区：
文献类型：
--
作者：
Yamauchi Y;Kohyama T;Jo T;Nagase T
慢性阻塞性肺疾病（COPD）的特点是持续气流受限，包括气道阻塞和实质肺气肿，并伴有弹性反冲力丧失。受迫振荡技术可以通过测量正常潮式呼吸期间的肺阻抗来检测肺功能的损伤。 COPD 中的呼吸阻力 (Rrs) 已得到充分研究，但轻度和中度 COPD 之间吸气相和呼气相的 Rrs 差异仍知之甚少。由于已知 COPD 中的气道阻塞在潮式呼吸期间会动态变化，并可能影响 Rrs，因此评估了轻度和中度 COPD 之间潮式呼吸期间 Rrs 的差异。东京大学医院（日本东京）招募了轻度（n = 13）和中度（n = 13）COPD 患者。 Rrs 是使用 MostGraph-01（Chest MI，Inc，东京，日本）测量的，它以频率和呼吸周期相关的方式在三维图形中描绘了 Rrs。 Rrs 在潮式呼吸期间以 4-35 Hz 进行评估。 COPD 潮式呼吸期间 Rrs 动态变化。中度 COPD 组的平均 Rrs 值显着高于轻度 COPD 组。中度慢性阻塞性肺病患者呼吸周期频率较高时的最大和最小 Rrs 值显着更高。在吸气-呼气呼吸分析中，中度组中 20 Hz 和 35 Hz 时的最大和最小 Rrs 值显着更大，而在 4 Hz 时，各组之间没有显着差异。 COPD 患者潮式呼吸期间 Rrs 发生动态变化。中度 COPD 中较高频率的 Rrs 值高于轻度 COPD。较高频率的 Rrs 可能反映 COPD 患者潮式呼吸中气道阻塞的程度，并且可能是评估 COPD 早期气道阻塞的有用标志。
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation consisting of airway obstruction and parenchymal emphysema, with loss of elastic recoil. The forced oscillation technique can detect impairment of lung function by measuring lung impedance during normal tidal breathing. Respiratory resistance (Rrs) in COPD has been well-studied, but the differences in Rrs in the inspiratory and expiratory phases between mild and moderate COPD remain poorly understood. Since airway obstruction in COPD is known to change dynamically during tidal breathing and might affect Rrs, the differences in Rrs during tidal breathing between mild and moderate COPD were evaluated. Mild (n = 13) and moderate (n = 13) COPD patients were recruited at Tokyo University Hospital (Tokyo, Japan). Rrs was measured using MostGraph-01 (Chest MI, Inc, Tokyo, Japan), which depicted Rrs in a frequency-and respiratory cycle-dependent manner in three-dimensional graphics. Rrs was evaluated at 4–35 Hz during tidal breathing. Rrs changed dynamically during tidal breathing in COPD. The mean Rrs values were significantly greater in the moderate COPD group than in the mild group. The maximal and minimal Rrs values at higher frequencies in the respiratory cycle were significantly greater in moderate COPD. In inspiratory–expiratory breath analysis, the maximal and minimal Rrs values at 20 Hz and 35 Hz were significantly greater in the moderate group, whereas at 4 Hz they did not differ significantly between the groups. Rrs changed dynamically during tidal breathing in patients with COPD. The Rrs values at higher frequencies were greater in moderate COPD than in mild COPD. Rrs at higher frequencies might reflect the degree of airway obstruction in tidal breathing in patients with COPD and might be a useful marker for evaluation of airway obstruction at an early stage of COPD.