Biologic Behavior and Clinical Outcome of 25 Dogs with Canine Appendicular Chondrosarcoma Treated by Amputation: A Veterinary Society of Surgical Oncology Retrospective Study
Biologic Behavior and Clinical Outcome of 25 Dogs with Canine Appendicular Chondrosarcoma Treated by Amputation: A Veterinary Society of Surgical Oncology Retrospective Study
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DOI：
10.1111/j.1532-950x.2009.00606.x
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发表时间：
2009-12-01
影响因子：
1.8
通讯作者：
Withrow, Stephen J.
中科院分区：
文献类型：
--
作者：
Farese, James P.;Kirpensteijn, Jolle;Withrow, Stephen J.
目的探讨单纯截肢治疗犬阑尾软骨肉瘤的生物学行为、临床结局及组织学分级对预后的影响。研究设计案例系列。动物犬（n=25）伴阑尾软骨肉瘤。方法对单行截肢治疗的犬阑尾软骨肉瘤患者进行病历分析。记录的信息包括信号、解剖位置、影像学表现和转移的发展。组织病理学诊断得到确认并分级（1、2或3）。生存曲线由Kaplan-Meier法生成，协变量（性别、年龄、体重和肿瘤分级）与生存之间的关联使用单变量比例风险模型进行评估。结果25只犬获得组织学切片。肺转移率如下：1-0%，2-31%,3-50%。总中位生存时间（MST）为979天。年龄、体重和性别与生存率无显著相关性(P= 0.16；分别为31)。生存率与肿瘤分级显著相关（P= 0.008）， 1级、2级和3级肿瘤犬的mst分别为6年、2.7年和0.9年。结论单纯截肢治疗犬阑尾软骨肉瘤是有效的。中低级别软骨肉瘤预后良好，而高级别肿瘤表现为侵袭性。临床意义阑尾软骨肉瘤的总体预后优于单独截肢或联合化疗治疗的阑尾骨肉瘤。
ObjectiveTo characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone.Study DesignCase series.AnimalsDogs (n=25) with appendicular chondrosarcoma.MethodsMedical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model.ResultsHistopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16; .33; and .31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively.ConclusionCanine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively.Clinical RelevanceThe overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.