Functional neural correlates of facial affect recognition impairment following TBI.
Functional neural correlates of facial affect recognition impairment following TBI.
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TBI 后面部情感识别障碍的功能神经相关性。
DOI：
10.1007/s11682-018-9889-x
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发表时间：
2019
影响因子：
3.2
通讯作者：
Duff,MelissaC
中科院分区：
文献类型：
--
作者：
Rigon,Arianna;Voss,MichelleW;Turkstra,LynS;Mutlu,Bilge;Duff,MelissaC
创伤性脑损伤（TBI）后的面部情感识别缺陷已被充分记录，因为它们与其他几个认知领域的障碍有关。然而，人们对情感识别缺陷的神经生物学机制知之甚少，特别是面部情感识别不同方面的机制（例如，感知和解释过程）。在目前的研究中，33名患有中度至重度TBI的成年人和24名人口统计学匹配的健康对照（HC）参与者完成了fMRI面部情感识别研究。在扫描仪中，参与者被要求将目标面孔的影响与（a）两张不同影响的面孔之一（感知条件）或（B）两个书面影响标签之一（解释条件）相匹配。在这两组中，我们发现通常参与情感识别的区域被激活。我们的研究结果表明，在知觉条件下，TBI的个人倾向于激活左背外侧前额叶皮层低于HC，和HC组内的个人具有较高的知觉情感识别分数显示出较高水平的激活在同一个大脑区域。在解释性情感识别方面特别受损的TBI患者在右侧梭状回的激活程度低于HC。此外，在标记条件下，TBI的个体倾向于去激活内侧前额叶区域低于HC。感兴趣的区域分析显示，TBI患者在FFA中对所有感兴趣的对比显示出比HC显著更少的激活。我们的研究结果表明，面部影响识别障碍后TBI的几个大脑区域的参与，并提供神经生物学支持的概念，面部影响识别的不同方面，可以在TBI后差异受损。
Facial affect recognition deficits following traumatic brain injury (TBI) have been well documented, as has their relationship with impairment in several other cognitive domains. However, little is known about the neurobiological mechanisms underlying affect recognition deficits, in particular mechanisms underlying different aspects of facial affect recognition (e.g., perceptual and interpretive processes). In the current study, 33 adults with moderate-to-severe TBI and 24 demographically matched healthy comparison (HC) participants completed an fMRI facial affect recognition study. While in the scanner, participants were asked to match the affect of a target face to either (a) one of two faces differing in affect (perceptual condition) or (b) one of two written affect labels (interpretative condition). In both groups we found activations in regions typically involved in affect recognition. Our results revealed that in the perceptual condition individuals with TBI tended to activate the left dorsolateral prefrontal cortex less than HCs, and within the HC group individuals with higher perceptual affect recognition scores showed higher levels of activation in the same brain region. Individuals with TBI who were specifically impaired at interpretative affect recognition showed less activation than HCs in the right fusiform gyrus. Moreover, in the labeling condition individuals with TBI tended to de-activate medial prefrontal regions less than HCs. A region of interest analysis revealed that individuals with TBI showed significantly less activation than HCs in the FFA for all the contrasts of interest. Our results suggest involvement of several brain regions in facial affect recognition impairment post TBI, and provide neurobiological support for the notion that distinct aspects of facial affect recognition can be differentially impaired following TBI.