Comparison of health-related quality of life (HRQoL) between ileal conduit diversion and orthotopic neobladder based on validated questionnaires: a systematic review and meta-analysis
Comparison of health-related quality of life (HRQoL) between ileal conduit diversion and orthotopic neobladder based on validated questionnaires: a systematic review and meta-analysis
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基于有效问卷的回肠导管改道与原位新膀胱的健康相关生活质量 (HRQoL) 比较：系统评价和荟萃分析
DOI：
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发表时间：
2018
影响因子：
3.5
通讯作者：
Xiaoping Zhang
中科院分区：
文献类型：
--
作者：
Hang;H. Yu;J. Bellmunt;J. Leow;X. Chen;Changcheng Guo;Hongmei Yang;Xiaoping Zhang
目的原位新膀胱（ONB）重建术在健康相关生活质量（HRQoL）方面是否上级回肠导管分流术（ICD）的问题仍存在争议。本研究的目的是进行一项荟萃分析，以比较后ICD和后ONB HRQoL膀胱cancer.MethodsA系统检索Medline，Embase，对照试验的科克伦中心注册，和欧洲泌尿外科协会（EAU）的年度会议摘要，美国泌尿外科协会（AUA）和国际泌尿外科学会（SIU）进行了截至2017年6月的研究，以确定使用经验证的问卷评估HRQoL的所有相关临床试验。然后进行系统回顾和荟萃分析。ResultsA共2507例患者从26个合格的研究。荟萃分析显示，在总体健康状况方面存在显著差异，有利于ONB患者（大规模毁灭性武器+9.13，p = 0.004），身体功能（大规模毁灭性武器+11.57，p = 0.0001），角色功能（大规模毁灭性武器+9.64，p = 0.002）和社会功能基于EORTC-QLQ-C30问卷和FACT问卷总分（WMD +6.80，p = 0.001）的WMD + 6.81，p = 0.03。然而，ONB患者比ICD患者更容易出现术后泌尿系统症状（WMD-22.19，p = 0.0001）。无论尿流改道（UD）手术的类型如何，HRQoL相对于术前状态的逐渐改善在术后12个月后趋于稳定。
PurposeThe question of whether orthotopic neobladder (ONB) reconstruction is superior to ileal conduit diversion (ICD) with respect to health-related quality of life (HRQoL) remains controversial. The goal of this study is to perform a meta-analysis to compare post-ICD and post-ONB HRQoL in patients with bladder cancer.MethodsA systematic search of Medline, Embase, the Cochrane Central Register of Controlled Trials, and the annual congress abstracts of the European Association of Urology (EAU), the American Urological Association (AUA) and the Société Internationale d’Urologie (SIU) up to June 2017 was conducted to identify all relevant clinical trials using validated questionnaires to assess HRQoL. A systematic review and meta-analysis were then performed.ResultsA total of 2507 patients from 26 eligible studies were included. Meta-analyses showed significant differences favouring ONB patients in global health status (WMD + 9.13, p = 0.004), physical functioning (WMD + 11.57, p = 0.0001), role functioning (WMD + 9.64, p = 0.002), and social functioning (WMD + 6.81, p = 0.03) based on the EORTC-QLQ-C30 questionnaire and in the total score of FACT questionnaire (WMD + 6.80, p = 0.001). However, ONB patients were more likely to have postoperative urinary symptoms than ICD patients (WMD − 22.19, p = 0.0001).ConclusionsONB patients are more likely to have a better global health status than ICD patients. Regardless of the type of urinary diversion (UD) surgery, a gradual improvement in HRQoL over preoperative status tended to stabilise after 12 months postoperatively.
影响因子：
45.3
作者：
CELLA, DF;TULSKY, DS;HARRIS, J
通讯作者：
HARRIS, J
荟萃分析中的中介者和调节者：我们不让渡渡鸟告诉我们哪些心理治疗应该获奖是有原因的。
影响因子：
5.9
作者：
ShadishJr,WR;Sweeney,RB
通讯作者：
Sweeney,RB