Bacteroides forsythus in adult gingivitis and periodontitis.
Bacteroides forsythus in adult gingivitis and periodontitis.
复制标题
福赛拟杆菌在成人牙龈炎和牙周炎中的作用。
DOI：
10.1111/j.1399-302x.1987.tb00299.x
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发表时间：
1987
影响因子：
--
通讯作者：
Slots,J
中科院分区：
文献类型：
--
作者：
Lai,CH;Listgarten,MA;Shirakawa,M;Slots,J
福赛氏拟杆菌是从人类口腔中新命名的一个物种，具有独特的细胞壁超微结构和一套独特的细胞表面抗原。以确定B的分布。在牙周区，采集了16例健康成人和11例轻度牙周炎、12例重度牙周炎和17例牙周炎患者的牙龈上菌斑。对27个病点的牙龈下标本进行了检查。间接免疫荧光显微镜检测到菌斑涂片中有连翘杆菌。兔抗体Tob。FDC335为一抗，荧光标记的羊抗兔抗体为二抗。B的比例之间有显著差异(P<；0.05)。健康受试者(0.2%)与轻度牙周炎(1.3%)、重度牙周炎(1.0%)和成人牙周炎(0.9%)患者的牙周上连翘苷样本进行比较。差异显著(p<；0.001)。在成年牙周炎患者的龈上(0.9%)和龈下(15.3%)样本中也检测到连翘比例。在另一项单独的研究中，对以前治疗过中重度成人牙周炎的患者进行了为期12个月的监测，以寻找疾病复发的证据。B的比例显著增加。与稳定部位相比，连翘在分解部位被发现。破坏的定义是从基准支架测量的距离基线2 mm或更多的附着丧失，或探测深度增加3 mm或更多。这些结果支持B。与晚期牙周炎和复发性牙周炎相关的连翘症。监测B组的龈下比例。连翘对维持治疗的患者可能有诊断价值。WhetherB。连翘会导致牙周病，还是牙周病变的继发性定殖者，这一点仍有待确定。
Bacteroides forsythus, a newly named species from the human mouth, possesses a distinct cell wall ultrastructure and a unique set of cell surface antigens. To determine the distribution ofB. forsythusin the periodontal region, supragingival plaque was collected from 16 healthy adults and from 11 adults with mild gingivitis, 12 with severe gingivitis and 17 with periodontitis. Subgingival samples from 27 diseased sites were examined as well.B. forsythuswas located in plaque smears by indirect immunofluorescence microscopy. Rabbit antibody toB. forsythusstrain FDC 335 constituted the primary antibody and fluoresceinlabelled goat‐antirabbit antibody the secondary antibody. There was a significant difference (p<0.05) between the proportions ofB. forsythusin supragingival samples of healthy subjects (0.2%) vs. individuals with mild gingivitis (1.3%), severe gingivitis (1.0%) and adult periodontitis (0.9%). A significant difference (p< 0.001) inB. forsythusproportions was also detected between supragingival (0.9%) and subgingival (15.3%) samples from adult periodontitis patients. In a separate study, patients previously treated for moderate to severe adult periodontitis were monitored over a 12‐month period for evidence of disease recurrence. A significant increase in the proportions ofB. forsythuswas found at sites with breakdown as compared to stable sites. Breakdown was defined as loss of attachment of 2 mm or more from base line, as measured from a reference stent, or a probing depth increase of 3 mm or more. These results support the assertion thatB. forsythusis associated with advanced periodontitis as well as recurrent periodontitis. Monitoring the subgingival proportions ofB. forsythusmay be of diagnostic value in patients on maintenance therapy. WhetherB. forsythuscauses periodontal disease or is a secondary colonizer of periodontal lesions remains to be determined.