Engineered toxins: New therapeutics
Engineered toxins: New therapeutics
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DOI：
10.1016/j.toxicon.2009.01.037
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发表时间：
2009-10-01
期刊：
影响因子：
2.8
通讯作者：
Foster, Keith A.
中科院分区：
文献类型：
--
作者：
Foster, Keith A.
梭菌神经毒素具有离散的结构域，具有不同的药理学特性。具有治疗潜力的神经毒素功能的方面包括特异性神经元结合、生物活性蛋白的细胞内（胞质）递送和抑制SNARE介导的分泌。理解神经毒素蛋白的结构功能关系使得能够产生并入神经毒素的选择结构域的重组蛋白，以产生在一系列临床应用中具有治疗潜力的新型蛋白。(C)2009爱思唯尔有限公司保留所有权利。
Clostridial neurotoxins possess discrete structural domains with distinct pharmacological properties. Aspects of neurotoxin function with therapeutic potential include specific neuronal binding, intracellular (cytosolic) delivery of biologically active protein and inhibition of SNARE-mediated secretion. Understanding the structure function relationship of the neurotoxin protein enables the creation of recombinant proteins incorporating select domains of the neurotoxins to produce novel proteins with therapeutic potential in a range of clinical applications. (C) 2009 Elsevier Ltd. All rights reserved.