A self-normalized, full time-resolved method for fluorescence diffuse optical tomography
A self-normalized, full time-resolved method for fluorescence diffuse optical tomography
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荧光漫射光学断层扫描的自归一化全时间分辨方法
DOI：
10.1364/oe.16.013104
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发表时间：
2008-08-18
期刊：
影响因子：
3.8
通讯作者：
Yamada, Yukio
中科院分区：
文献类型：
--
作者：
Gao, Feng;Zhao, Huijuan;Yamada, Yukio
基于有限元有限时差光子扩散建模和牛顿-拉夫森反演框架，先前应用于漫射光学断层扫描的全时间分辨方案已扩展到时域荧光漫射光学断层扫描体系。使用全时间分辨数据的优点是双重的：它有助于评估时域模式的内在性能，以提高图像质量，并为评估计算效率高的基于特征数据的算法提供有价值的参考，并提供自归一化的实现，以消除系统的缩放因子校准和光谱特征评估的必要性，并克服逆境。 系统不稳定。我们使用模拟数据验证了所提出的方法，并评估了其同时恢复荧光产量和寿命的性能以及其在图像重建保真度方面相对于特征数据方法的优越性。 (C) 2008 年美国光学学会。
A full time-resolved scheme that has been previously applied in diffuse optical tomography is extended to time-domain fluorescence diffuse optical tomography regime, based on a finite-element-finite-time-difference photon diffusion modeling and a Newton-Raphson inversion framework. The merits of using full time-resolved data are twofold: it helps evaluate the intrinsic performance of time-domain mode for improvement of image quality and set up a valuable reference to the assessment of computationally efficient featured-data-based algorithms, and provides a self-normalized implementation to preclude the necessity of the scaling-factor calibration and spectroscopic-feature assessments of the system as well as to overcome the adversity of system instability. We validate the proposed methodology using simulated data, and evaluate its performances of simultaneous recovery of the fluorescent yield and lifetime as well as its superiority to the featured-data one in the fidelity of image reconstruction. (C) 2008 Optical Society of America.