An in vitro Study to Investigate Biomechanical Responses of Peripheral Nerves in Hypoxic Neonatal Piglets
An in vitro Study to Investigate Biomechanical Responses of Peripheral Nerves in Hypoxic Neonatal Piglets
复制标题
调查缺氧新生仔猪周围神经生物力学反应的体外研究
DOI：
10.1115/1.4051283
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Balasubramanian, Sriram
中科院分区：
文献类型：
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作者：
Singh, Anita;Magee, Rachel;Balasubramanian, Sriram
尽管在复杂的分娩场景中会发生新生儿缺氧和周围神经损伤，但缺氧对新生儿周围神经生物力学反应的影响尚未被研究。本研究对8头正常仔猪和8头缺氧3~5日龄仔猪的臂丛神经和胫神经进行了单轴拉伸直至断裂的测试，速率分别为0.01 mm/S和10 mm/S。在0.01和10 mm/S速率下，缺氧新生猪的臂丛神经和胫神经的破坏载荷、应力和弹性模量均显著低于相应的正常组织。仅在10 mm/S速率下，缺氧的新生儿BP神经的失效应变显著低于正常BP神经。这是第一个可获得的数据表明，与正常组织相比，缺氧新生儿周围神经的力学行为较弱，并为了解缺氧新生仔猪周围神经的生物力学反应提供了依据。
Despite occurrence of neonatal hypoxia and peripheral nerve injuries in complicated birthing scenarios, the effect of hypoxia on the biomechanical responses of neonatal peripheral nerves is not studied. In this study, neonatal brachial plexus (BP) and tibial nerves, obtained from eight normal and eight hypoxic 3–5-day-old piglets, were tested in uniaxial tension until failure at a rate of 0.01 mm/s or 10 mm/s. Failure load, stress, and modulus of elasticity were reported to be significantly lower in hypoxic neonatal BP and tibial nerves than respective normal tissue at both 0.01 and 10 mm/s rates. Failure strain was significantly lower in the hypoxic neonatal BP nerves only at 10 mm/s rate when compared to normal BP nerve. This is the first available data that indicate weaker mechanical behavior of hypoxic neonatal peripheral nerves as compared to normal tissue and offer an understanding of the biomechanical responses of peripheral nerves of hypoxic neonatal piglets.