Tumor Microenvironment Varies under Different TCM ZHENG Models and Correlates with Treatment Response to Herbal Medicine.
Tumor Microenvironment Varies under Different TCM ZHENG Models and Correlates with Treatment Response to Herbal Medicine.
复制标题
不同中医郑氏模型下肿瘤微环境有所不同，并与草药治疗反应相关
DOI：
10.1155/2012/635702
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wang K
中科院分区：
文献类型：
--
作者：
Chen Z;Chen LY;Wang P;Dai HY;Gao S;Wang K
在中国传统医学（TCM）中，病理诊断和治疗处方的选择是基于一种称为辨证或证的体征和症状的鉴别方法。中医的基石，证，依赖于通过观察，听诊和嗅觉，询问和触诊收集临床信息。然而，ZHENG的生物分子基础仍不清楚。本研究以胰腺癌三大证-湿热证、脾虚证、血瘀证建立小鼠胰腺癌移植模型。我们发现，不同ZHENG模型的肿瘤表现出显著改变的癌症相关成纤维细胞（CAF）增殖活性和肿瘤相关巨噬细胞（TAM）浸润，这导致CAF和TAM衍生的分泌细胞因子（如SDF-1和CCL 5）水平改变。ZHENG模型类型也显著影响肿瘤生长，并且向ZHENG模型施用草药改变了肿瘤微环境。因此，本研究部分揭示了中医证治胰腺癌的分子基础。
In traditional Chinese medicine (TCM), diagnosis of pathology and choice of treatment prescriptions are based on a method of differentiation of signs and symptoms known as syndrome differentiation or ZHENG. The cornerstone of TCM, ZHENG, relies on the gathering of clinical information through inspection, auscultation and olfaction, inquiry, and palpation. However, the biomolecular basis of the ZHENG remains unclear. In this study, we established mouse xenograft pancreatic cancer models with Shi-Re (Dampness-Heat), Pi-Xu (Spleen-Deficiency), or Xue-Yu (Blood-Stasis) ZHENG, which are regarded as the three major ZHENGs in pancreatic cancer. We found that tumors of the different ZHENG models exhibited significantly altered cancer-associated fibroblast (CAF) proliferative activity and tumor-associated macrophage (TAM) infiltration, which led to altered levels of CAF- and TAM-derived secreted cytokines such as SDF-1 and CCL5. The ZHENG model type also significantly influenced tumor growth, and administration of herbal medicine to the ZHENG model modified the tumor microenvironment. Therefore, this study partially unveiled the molecular basis of TCM ZHENG in pancreatic cancer.
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影响因子：
11.2
作者：
Marchesi, F;Monti, P;Allavena, P
通讯作者：
Allavena, P
影响因子：
24.5
作者：
Neesse, Albrecht;Michl, Patrick;Tuveson, David A.
通讯作者：
Tuveson, David A.
影响因子：
6.4
作者：
Langley, Robert R.;Fidler, Isaiah J.
通讯作者：
Fidler, Isaiah J.
DOI：
10.1056/nejmoa0905680
发表时间：
2010-03-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Steidl C;Lee T;Shah SP;Farinha P;Han G;Nayar T;Delaney A;Jones SJ;Iqbal J;Weisenburger DD;Bast MA;Rosenwald A;Muller-Hermelink HK;Rimsza LM;Campo E;Delabie J;Braziel RM;Cook JR;Tubbs RR;Jaffe ES;Lenz G;Connors JM;Staudt LM;Chan WC;Gascoyne RD
通讯作者：
Gascoyne RD
影响因子：
2.9
作者：
Ouyang H;Wang P;Meng Z;Chen Z;Yu E;Jin H;Chang DZ;Liao Z;Cohen L;Liu L
通讯作者：
Liu L