[Regulations of osteoclast formation and function by Wnt signals.]
[Regulations of osteoclast formation and function by Wnt signals.]
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DOI：
10.20837/4201903309
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发表时间：
2019-01-01
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影响因子：
--
通讯作者：
Koide, Masanori
中科院分区：
文献类型：
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作者：
Kobayashi, Yasuhiro;Uehara, Shunsuke;Koide, Masanori
Wnt配体激活β -连环蛋白依赖的典型和独立的非典型信号通路。最近的研究证实了Wnt/ β -连环蛋白信号在骨生长中的重要性。针对Wnt抑制剂sclerostin的抗体和针对Wnt抑制剂Dickkopf-1的抗体已被证明对增加骨量有效。除了对骨形成的影响外，Wnt信号在骨吸收中的作用也逐渐被阐明。本文就Wnt信号在破骨细胞形成中的作用、破骨细胞对硬化蛋白表达的调控等方面的研究进展作一综述。
Wnt ligands activate beta-catenin-dependent canonical and -independent non-canonical signaling pathways. Recent studies established importance of Wnt/beta-catenin signaling in bone accrual. Antibodies against the Wnt inhibitor sclerostin and those against the Wnt inhibitor Dickkopf-1 have been shown to be effective for increasing bone mass. In addition to their effects on bone formation, roles of Wnt signals in bone resorption are gradually clarified. In this review, we would like to introduce recent advances in roles of Wnt signals in osteoclast formation and functions and regulation of sclerostin expression by osteoclasts.