Chemical approaches for detection and destruction of nerve agents
Chemical approaches for detection and destruction of nerve agents
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DOI：
10.1039/c3ob40324f
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发表时间：
2013-01-01
影响因子：
3.2
通讯作者：
Rebek, Julius, Jr.
中科院分区：
文献类型：
--
作者：
Ajami, Dariush;Rebek, Julius, Jr.
自从有机磷（OP）化合物作为神经毒剂和杀虫剂被引入以来，人们一直在研究如何处理其对人类的毒性。有关于传感、预处理、解毒剂、解毒剂和治疗的研究。所有这些努力都有一些重叠，因为它们必须处理磷原子在各种情况下的反应性。环境范围从大空间，空气中稀薄的蒸汽，到与OP剂反应的酶-乙酰胆碱酯酶（AChE）或丁酰胆碱酯酶（BuChE）活性部位的非常小的空间。
Since the introduction of organophosphorus (OP) compounds as nerve agents and pesticides, methods of dealing with their toxicity to humans have been intensely researched. There are studies on sensing, pretreatments, prophylactics, antidotes and therapies. There is some overlap in all of these endeavors because they have to deal with the reactivity of the phosphorus atom in various contexts. The contexts range from large spaces, the thinly spread vapors in the air, to very small spaces in the active sites of enzymes - acetylcholinesterase (AChE) or butyrylcholinesterase (BuChE) - that have reacted with the OP agent.