A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring.
A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring.
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DOI：
10.1038/ncomms11650
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发表时间：
2016-05-23
影响因子：
16.6
通讯作者：
Mercier PP
中科院分区：
文献类型：
--
作者：
Imani S;Bandodkar AJ;Mohan AM;Kumar R;Yu S;Wang J;Mercier PP
灵活、可穿戴的传感设备可以产生有关人体受试者潜在生理的重要信息，用于实时健康和健身监测。尽管在柔性生物传感器的制造方面取得了重大进展，但大多数设计只测量了少量的物理或电生理参数，而忽略了生物标志物提供的丰富的化学信息。在这里，我们介绍了一种可穿戴在皮肤上的混合传感系统，它可以同时实时监测生化(乳酸)和电生理信号(心电图)，从而比仅通过物理或电生理传感器进行更全面的健康监测。这两种传感模式包括一个三电极安培乳酸生物传感器和一个双极心电传感器，它们共同制造在柔性衬底上并安装在皮肤上。人体实验表明，可以同时测量生理化学和电生理学，而串扰可以忽略不计，从而实现了一种新型的混合传感设备。可穿戴传感器可以为用户提供持续、方便的反馈，但通常只关注少量的生理参数。在这里，作者报告了一种皮肤佩戴的传感系统，它将乳酸检测的生物传感器和心电图仪结合在一个贴片中，并应用于运动监测。
Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a small number of physical or electrophysiological parameters, and neglect the rich chemical information available from biomarkers. Here, we introduce a skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram), for more comprehensive fitness monitoring than from physical or electrophysiological sensors alone. The two sensing modalities, comprising a three-electrode amperometric lactate biosensor and a bipolar electrocardiogram sensor, are co-fabricated on a flexible substrate and mounted on the skin. Human experiments reveal that physiochemistry and electrophysiology can be measured simultaneously with negligible cross-talk, enabling a new class of hybrid sensing devices. Wearable sensors can provide continuous, convenient feedback for users but typically focus on a small number of physiological parameters. Here, the authors report a skin-worn sensing system that combines a biosensor for lactate detection with an electrocardiogram in one patch, with applications for exercise monitoring.