Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome.
Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome.
复制标题
患有全身性幼年特发性关节炎和未识别的巨噬细胞激活综合征的患者骨髓中白细胞介素 18 的表达增加。
作者：
N. Maeno;S. Takei;H. Imanaka;Kimie Yamamoto;K. Kuriwaki;Y. Kawano;H. Oda
促炎症细胞因子的异常诱导被认为在系统性幼年特发性关节炎和成人型斯蒂尔病的发病机制中起关键作用。特别是白介素18(IL-18)已被报道为这两种疾病的关键细胞因子的候选者；然而，IL-18的来源尚不清楚。为了阐明其来源，我们对一例系统性JIA和巨噬细胞激活综合征患儿尸检时采集的不同器官标本进行了免疫组织化学染色。我们的结果表明，在骨髓中有大量的细胞表达IL-18，而在其他器官中没有表达。这一发现提示骨髓是血清IL-18升高的来源，并增加了在本病中骨髓中IL-18也诱导其他促炎细胞因子的可能性。骨髓可能是系统性JIA发病过程中的重要器官。
The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult-onset Still's disease. Interleukin-18 (IL-18) in particular has been reported to be a candidate for the key cytokine in both diseases; however, the origin of IL-18 is unclear. To clarify the origin, we investigated specimens from various organs obtained during autopsy of a child with systemic JIA and macrophage activation syndrome, using immunohistochemical staining. Our results showed a high number of cells expressing IL-18 in the bone marrow but not in the other organs. This finding suggests that bone marrow is the origin of increased serum IL-18 and raises the possibility that other proinflammatory cytokines are also induced by IL-18 in bone marrow in this disease. Bone marrow may be an essential organ in the pathogenesis of systemic JIA.
影响因子：
5.1
作者：
Grom, AA;Villanueva, J;Filipovich, A
通讯作者：
Filipovich, A