Synthetic approach towards nakadomarin A: efficient synthesis of the central tetracyclic core
Synthetic approach towards nakadomarin A: efficient synthesis of the central tetracyclic core
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DOI：
10.1016/s0040-4039(01)01792-0
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发表时间：
2001-11-19
影响因子：
1.8
通讯作者：
Nakagawa, M
中科院分区：
文献类型：
--
作者：
Nagata, T;Nishida, A;Nakagawa, M
以4-氧代-3-哌啶甲酸甲酯为起始原料，有效地合成了Nakadomarin A的四环核心。反应的关键步骤是呋喃分子内环化为N-酰基环戊烯离子，形成应变中心环戊烯环。(C)2001爱思唯尔科技有限公司版权所有。
An efficient synthesis of the tetracyclic core of nakadomarin A was accomplished starting from methyl 4-oxo-3-piperidinecarboxylate. The key steps were intramolecular cyclization of furan to N-acyliminium ions to construct the strained central cyclopentene ring. (C) 2001 Elsevier Science Ltd. All rights reserved.