Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols
Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols
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单半乳糖二酰基甘油的合成及结构-抗肿瘤活性关系
DOI：
10.1016/s0960-894x(01)80577-1
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发表时间：
1994
影响因子：
2.7
通讯作者：
K. Yazawa
中科院分区：
文献类型：
--
作者：
A. Nagatsu;Miyako Watanabe;K. Ikemoto;M. Hashimoto;N. Murakami;J. Sakakibara;H. Tokuda;H. Nishino;A. Iwashima;K. Yazawa
利用对甲氧基苄基保护糖基上的羟基，合成了单半乳糖基甘油二酯（MGDG，1a-t）。MGDG（1a-t）及相关化合物对EB病毒早期抗原活化的抑制活性被评价为抗肿瘤促进活性，并且具有油酰基的MGDG（1c，h-j，p，s）显示出较强的活性。
Monogalactosyl diacylglycerols (MGDG,1a–t) were synthesized utilizingp-methoxybenzyl group for protection of hydroxyl groups at sugar moiety. Inhibitory activity of MGDG (1a–t) and related compounds on Epstein-Barr virus early antigen activation was evaluated as anti-tumor-promoting activity, and MGDG with oleoyl group (1c,h–j,p,s) showed strong activity.