The pediatric end-stage liver disease (PELD) model as a predictor of survival benefit and posttransplant survival in pediatric liver transplant recipients
The pediatric end-stage liver disease (PELD) model as a predictor of survival benefit and posttransplant survival in pediatric liver transplant recipients
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DOI：
10.1002/lt.20703
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发表时间：
2006-03-01
影响因子：
4.6
通讯作者：
Goss, JA
中科院分区：
文献类型：
--
作者：
Barshes, NR;Lee, TC;Goss, JA
儿科终末期肝病（PELD）模型准确地估计了儿科肝移植候选人的90天等待名单死亡率，但目前尚不清楚PELD是否可以识别将从接受肝移植（LT）中获得生存益处的患者，是否与移植后生存相关，或者是否可以识别LT无效的患者。在2001年至2004年期间接受LT的儿科患者通过器官共享联合网络器官采购和移植网络数据库登记。根据LT后第一年获得的生命年来衡量生存益处。1，247例患者的完整数据可用：53%在原位肝移植（奥尔特）时被列为状态1，而其余47%有PELD评分。仅PELD评分为17+或被指定为器官共享联合网络状态1的患者在LT后1年内获得生存获益; PELD评分为
The pediatric end-stage liver disease (PELD) model accurately estimates 90-day waitlist mortality for pediatric liver transplant candidates, but it has been unclear if PELD can identify patients who will derive survival benefit from undergoing liver transplantation (LT), if it correlates with posttransplant survival, or if it can identify patients for whom LT would be futile. Pediatric patients who underwent LT between 2001 and 2004 were enrolled through the United Network for Organ Sharing Organ Procurement and Transplant Network database. Survival benefit was measured in terms of life-years gained during the first year after LT. Complete data were available for 1,247 patients: 53% were listed as Status 1 at the time of orthotopic liver transplantation (OLT), while the remaining 47% had PELD scores. Only in patients with a PELD of 17+ or those designated as United Network for Organ Sharing Status 1 derived a survival benefit within 1 year of LT; patients with a PELD score of