Age- and sex-specific yield of Barrett's esophagus by endoscopy indication
Age- and sex-specific yield of Barrett's esophagus by endoscopy indication
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DOI：
10.1016/j.gie.2009.06.035
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发表时间：
2010-01-01
影响因子：
7.7
通讯作者：
Eisen, Glenn
中科院分区：
文献类型：
--
作者：
Rubenstein, Joel H.;Mattek, Nora;Eisen, Glenn
背景：Barrett氏综合征是食管腺癌的先兆，两者都与GERD有关。SLII建议筛查GERD患者的Barrett‘s食道，但不知道应该筛查哪些患者以及在什么年龄进行筛查。目的：确定按性别和内窥镜检查适应症进行Barrett’s食管镜检查的年龄特定的产率。设计：回顾性横断面研究。设置：临床结果研究计划(CORI)的国家内窥镜数据库。患者：共有155,641名患者在CORI的一个部位进行第一次内窥镜检查。主要结果测量：Barrett‘s食道的年龄特定的产率。结果：在患有GERD的白人男性中，Barrett‘s食道的产量从成体早期(第三个十年为2.1%)到成年中期(第六个十年为9.3%)急剧增加，然后进入平台期(第八个十年减去第六个十年的差值为-11%1-95%C l；-3.9%至-1.7%)。患有GERD的中年白人女性与非GERD的白人男性Barrett‘s食管产率差异无统计学意义(差值为-0.46%；95%CI，-1.23%~0.31%)。限制：选择胃镜检查可能产生的偏差和GERD状态误判的可能性。结论：在50岁左右的GERD白人男性中，诊断Barrett’s食管炎的上消化道镜产率迅速增加，然后达到平台期。与没有GERD的白人男性相比，患有GERD的白人女性没有增加风险。(胃肠内卷2010；71：21-7。)
Background: Barrett's esophaps is a precursor of esophagel adenocarcinoma, both of which are associated with GERD. Screening GERD patients for Barrett's esophagus has been SLII suggested, but it is not known which patiets should be screened and at what age.Objective: To determine the age-specific yield of endoscopy for Barrett's esophagus stratofoed by sex and indication for endoscopyDesign: retrospective cross-sectional study.Setting: national endoscopic database of the clinical outcomes research initiative (CORI).Patients: A total of 155,641 patients undergoing their first endoscopy at one of the cori sites for clinical indicatons.Main Outcome Measurements: Age-specific yield of barrett's esophagus.Results: Among white men With GERD, the yield of Barrett's esophagus increase steeply from early adulthood (2.1% in the third decade of life) to middle adulthood (9.3% it, the sixth decade) and then plateaus (the difference for the eighth decade minus the sixth decade is -11%1- 95% Cl; -3.9% to -1.7%). There is no difference ill the yield of barrett's esophagus between middle-aged white women with GERD and white men without GERD (difference is -0.46%; 95% Cl, -1.23% to 0.31%).Limitations: Possible bias by selection for endoscopy and the potential for misclassification of GERD status.Conclusions: The yield Of Upper endoscop\For the diagnosis of Barrett's esophagus increases rapidly among white men with GERD until approximately age 50 and then reaches a plateau. White women with GERD are at no increased risk compared with white men without GERD. (Gastrointest Endosc 2010;71:21-7.)