Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis.

Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis.
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DOI:
10.1016/j.biopsych.2015.03.021
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发表时间:
2015-06-15
影响因子:
10.6
通讯作者:
Gordon JA
Gordon JA
中科院分区:
医学1区
文献类型:
--
作者:
Rosen AM;Spellman T;Gordon JA

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精神分裂症是由多种危险因素引起的,并导致类似的多种症状。电生理内表型介于风险和症状之间,并有可能将两者联系起来。本文描述的啮齿动物模型的电生理学研究表明,广泛不同的危险因素会导致一组相似的核心电生理内表型,这表明共享神经生物学底物的可能性。
Schizophrenia is caused by a diverse array of risk factors, and results in a similarly diverse set of symptoms. Electrophysiological endophenotypes lie between risks and symptoms, and have the potential to link the two. Electrophysiological studies in rodent models, described here, demonstrate that widely differing risk factors result in a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared neurobiological substrate.
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