DEVELOPMENT OF OBESITY IN ZUCKER OBESE (FA/FA) RAT IN ABSENCE OF HYPERPHAGIA
DEVELOPMENT OF OBESITY IN ZUCKER OBESE (FA/FA) RAT IN ABSENCE OF HYPERPHAGIA
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DOI：
10.1152/ajpendo.1980.238.3.e284
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
GREENWOOD, MRC
中科院分区：
文献类型：
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作者：
CLEARY, MP;VASSELLI, JR;GREENWOOD, MRC
自由喂养的遗传性肥胖大鼠具有高吞噬、高胰岛素血症和高胆固醇血症，并且与其瘦的同窝出生大鼠相比具有增加的脂肪细胞大小和数量。当fafa大鼠在一生中被阻止表现出过度进食时，完全肥胖综合征仍然会发展。终生限食不能防止fafa大鼠脂蛋白脂酶的增加。外周代谢适应，可能在脂质代谢中，明显导致限制性肥胖大鼠的饮食基质优先分流至脂肪组织，伴随着其他组织的减少。
The free-feeding, genetically obese rat is hyperphagic, hyperinsulinemic and hypertriglyceridemic and has increased fat cell size and number compared to its lean littermate. When fafa rats are prevented from expressing hyperphagia throughout life, the complete obese syndrome still develops. Life-long food restriction does not prevent increased lipoprotein lipase in the fafa rat. A peripheral metabolic adaptation, probably in lipid metabolism apparently results in preferential shunting of dietary substrate in the restricted obese rats to adipose tissue with concomitant decreases in other tissues.