Are patients with Down syndrome vulnerable to life-threatening COVID-19?
Are patients with Down syndrome vulnerable to life-threatening COVID-19?
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DOI：
10.1007/s13760-020-01373-8
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发表时间：
2020-05-22
影响因子：
2.7
通讯作者：
Spaepen, Ann
中科院分区：
文献类型：
--
作者：
De Cauwer, Harald;Spaepen, Ann
唐氏综合征患者呼吸道合胞病毒和H1N1相关死亡的风险增加。目前尚无关于唐氏综合征患者中COVID-19的文献。我们描述了4例唐氏综合征患者在COVID-19爆发期间的临床过程。在所有4例患者中，病程均为重度，3例患者需住院治疗，1例患者发生致死性结局。另一名患者在我们机构接受支持性护理。我们的病例系列是第一份关于唐氏综合征患者中COVID-19危及生命的疾病过程风险可能增加的报告。适当的监测、保持社交距离和使用个人防护设备对于降低患者的发病率和死亡率至关重要。
Patients with Down syndrome are at increased risk of respiratory syncytial virus- and H1N1-related death. Literature on COVID-19 in Down syndrome patients is unavailable thus far. We describe the clinical course of 4 patients with Down syndrome during an outbreak of COVID-19. In all four patients, disease course was severe, warranting hospital care in three patients, with fatal outcome in one patient. Another patient receives supportive care in our institution. Our case series is the first report on probable increased risk of life-threatening disease course of COVID-19 in patients with Down syndrome. Proper surveillance, the adherence of social distancing, and the use of personal protective equipment will be essential in reducing morbidity and mortality in our patients.