Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey
Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey
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DOI：
10.1136/bmj.c2451
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发表时间：
2010-05-27
影响因子：
105.7
通讯作者：
Hamer, Mark
中科院分区：
文献类型：
--
作者：
de Oliveira, Cesar;Watt, Richard;Hamer, Mark
目的探讨自我报告的刷牙行为是否与心血管疾病、炎症标志物(C反应蛋白)和凝血指标(纤维蛋白原)有关。设计基于全国人群的调查。建立苏格兰健康调查，抽取苏格兰家庭中具有全国代表性的一般人群样本。参与者11869名男性和女性，平均年龄50岁(SD 11)。主要结果根据自我报告的刷牙频率评估口腔卫生。调查前瞻性地与临床医院记录相联系，并使用COX比例风险模型根据口腔卫生来估计心血管疾病事件或死亡的风险。结果在平均8.1(SD 3.4)年的随访期内，共有555例心血管疾病事件发生，其中170例死亡。在大约74%(411)的心血管疾病事件中，主要诊断为冠心病。报告口腔卫生不良(从不/很少刷牙)的参与者患心血管疾病事件的风险增加(风险比1.7，95%可信区间1.3至2.3；P
Objective To examine if self reported toothbrushing behaviour is associated with cardiovascular disease and markers of inflammation (C reactive protein) and coagulation (fibrinogen).Design National population based survey.Setting Scottish Health Survey, which draws a nationally representative sample of the general population living in households in Scotland.Participants 11 869 men and women, mean age 50 (SD 11).Main outcome measures Oral hygiene assessed from self reported frequency of toothbrushing. Surveys were linked prospectively to clinical hospital records, and Cox proportional hazards models were used to estimate the risk of cardiovascular disease events or death according to oral hygiene. The association between oral hygiene and inflammatory markers and coagulation was examined in a subsample of participants (n=4830) by using general linear models with adjustments.Results There were a total of 555 cardiovascular disease events over an average of 8.1 (SD 3.4) years of follow-up, of which 170 were fatal. In about 74% (411) of cardiovascular disease events the principal diagnosis was coronary heart disease. Participants who reported poor oral hygiene (never/rarely brushed their teeth) had an increased risk of a cardiovascular disease event (hazard ratio 1.7, 95% confidence interval 1.3 to 2.3; P