Lipoprotein(a) as a determinant of coronary heart disease in young women.
Lipoprotein(a) as a determinant of coronary heart disease in young women.
复制标题
脂蛋白（a）是年轻女性冠心病的决定因素。
DOI：
10.1161/01.cir.95.2.329
复制
发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
Rydén,L
中科院分区：
文献类型：
--
作者：
Orth-Gomér,K;Mittleman,MA;Schenck-Gustafsson,K;Wamala,SP;Eriksson,M;Belkic,K;Kirkeeide,R;Svane,B;Rydén,L
脂蛋白（a）[Lp（a）]是男性冠心病的危险因素。Lp（a）在妇女中的作用，但是，是不太清楚的。方法和结果我们研究的能力Lp（a）预测冠心病在人口为基础的病例对照研究的妇女65岁或更年轻的谁住在更大的斯德哥尔摩地区。受试者均为1991年2月至1994年2月期间因急性CHD事件住院的患者。从城市人口普查中随机选择对照组，并按年龄和集水区与患者相匹配。在住院后3个月通过使用免疫比浊法（Incstar）测量Lp（a），所述免疫比浊法（Incstar）校准到西北脂质研究实验室（Northwest Lipid Research Laboratories）（变异系数<9%）。在292例连续患者中，110例（37%）因急性心肌梗死住院，182例（63%）因心绞痛住院。患者和对照受试者的平均年龄为56±7岁。在参与者中，74例患者（25%）和84例对照受试者（29%）为绝经前。Lp（a）在患者和对照组中的分布高度偏斜，范围为0.001 - 1.14 g/L。Lp（a）最高四分位数与最低四分位数的CHD的危险度调整比值比为2.3（95%置信区间[CI]，1.4 - 3.7）。校正年龄、吸烟、教育、体重指数、收缩压、总胆固醇、甘油三酯和HDL后，比值比为2.9（95%CI，1.6 - 5.0）。当心肌梗死和心绞痛患者与其各自的对照组相比时，优势比相似。比值比分别为5.1（95%CI，1.4至18.4）和2.4（95%CI，1.3至4.5）在绝经前和绝经后women.ConclusionsThese结果表明，脂蛋白（a）是一个决定因素冠心病在绝经前和绝经后妇女。
BackgroundLipoprotein(a) [Lp(a)] appears to be a risk factor for coronary heart disease (CHD) in men. The role of Lp(a) in women, however, is less clear.Methods and ResultsWe examined the ability of Lp(a) to predict CHD in a population-based case-control study of women 65 years of age or younger who lived in the greater Stockholm area. Subjects were all patients hospitalized for an acute CHD event between February 1991 and February 1994. Control subjects were randomly selected from the city census and were matched to patients by age and catchment area. Lp(a) was measured 3 months after hospitalization by use of an immunoturbidometric method (Incstar) calibrated to the Northwest Lipid Research Laboratories (coefficient of variation was <9%). Of the 292 consecutive patients, 110 (37%) were hospitalized for an acute myocardial infarction, and 182 were hospitalized (63%) for angina pectoris. The mean age for both patients and control subjects was 56±7 years. Of participants, 74 patients (25%) and 84 control subjects (29%) were premenopausal. The distributions of Lp(a) were highly skewed in both patients and control subjects, with a range from 0.001 to 1.14 g/L. Age-adjusted odds ratio for CHD in the highest versus the lowest quartile of Lp(a) was 2.3 (95% confidence interval [CI], 1.4 to 3.7). After adjustment for age, smoking, education, body mass index, systolic blood pressure, total cholesterol, triglycerides, and HDL, the odds ratio was 2.9 (95% CI, 1.6 to 5.0). The odds ratios were similar when myocardial infarction and angina patients were compared with their respective control subjects. The odds ratios were 5.1 (95% CI, 1.4 to 18.4) and 2.4 (95% CI, 1.3 to 4.5) in premenopausal and postmenopausal women, respectively.ConclusionsThese results suggest that Lp(a) is a determinant of CHD in both premenopausal and postmenopausal women.