Site of action of chlorpromazine and mephenesin in experimental tetanus.
Site of action of chlorpromazine and mephenesin in experimental tetanus.
复制标题
氯丙嗪和美菲新在实验性破伤风中的作用部位。
DOI：
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发表时间：
1962
期刊：
影响因子：
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通讯作者：
R. Webster
中科院分区：
文献类型：
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作者：
R. Webster
本文报道了氯丙嗪和美芬甘油醚对家兔的抗破伤风作用。氯丙嗪在脊髓动物中的活性与完整和去大脑动物不同，并取决于脑干切片的水平。美芬甘油醚在所有制剂中同样有效，可能通过阻断脊髓运动通路的传递来抑制破伤风。
The anti-tetanus activities of chlorpromazine and mephenesin have been determined quantitatively in intact, spinal and decerebrate rabbits with local tetanus. The activity of chlorpromazine in the spinal animal differed from that in the intact and decerebrate animal and depended on the level of brain-stem section. Mephenesin was equally effective in all preparations and probably suppressed tetanus by blocking transmission in motor pathways in the spinal cord.