Tourette's syndrome and deep brain stimulation
Tourette's syndrome and deep brain stimulation
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DOI：
10.1136/jnnp.2004.043273
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发表时间：
2005-07-01
影响因子：
11
通讯作者：
Agid, Y
中科院分区：
文献类型：
--
作者：
Houeto, JL;Karachi, C;Agid, Y
在这项前瞻性双盲随机“N of 1”研究中，一名重度抽动秽语综合征患者接受双侧高频刺激丘脑中央-束旁复合体（Ce-Pf）、苍白球（GPi）内部或两者。刺激任一靶点可使抽动严重程度改善70%，明显改善了大便失禁，并消除了自我伤害。严重形式的抽动秽语综合征可能受益于基底神经节内神经元回路的刺激，从而证实了边缘纹状体-苍白球-丘脑-皮质系统功能障碍在这种疾病中的作用。
In this prospective double blind randomised "N of 1'' study, a patient with a severe form of Tourette's syndrome was treated with bilateral high frequency stimulation of the centromedian-parafascicular complex (Ce-Pf) of the thalamus, the internal part of the globus pallidus (GPi), or both. Stimulation of either target improved tic severity by 70%, markedly ameliorated coprolalia, and eliminated self injuries. Severe forms of Tourette's syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the role of the dysfunction of limbic striato-pallido-thalamo-cortical systems in this disorder.