The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression.
The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression.
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DOI：
10.1038/ki.2012.197
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发表时间：
2012-10
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
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尽管在大多数IgAN患者中发现血清中高水平的半乳糖缺乏症iga1 （IgA肾病（IgAN）的重要生物标志物），但其与疾病严重程度和进展的关系尚不清楚。为了澄清这一点，我们前瞻性地招募了275名IgAN患者，随访时间中位数为47个月（12-96个月）。在诊断时使用基于凝集素的ELISA检测血清半乳糖缺乏- iga1，并使用Cox比例风险法建立肾脏生存模型。IgAN患者血清中半乳糖缺乏症iga1水平高于健康对照组。重要的是，在调整分析中，较高水平的半乳糖缺陷- iga1与肾功能恶化的风险增加独立相关，自然对数转换的半乳糖缺陷- iga1浓度的每标准差的风险比为1.44。与第一个四分位数相比，肾衰竭的风险增加，因此半乳糖缺乏iga1浓度的第二个四分位数的风险比为2.47，第三个四分位数为3.86，第四个四分位数为4.76。因此，血清中半乳糖缺乏症iga1水平升高与IgAN预后不良相关。
Although high serum levels of galactose-deficient-IgA1 (an important biomarker of IgA nephropathy (IgAN)), are found in most patients with IgAN, their relationship to disease severity and progression remains unclear. To help clarify this we prospectively enrolled 275 patients with IgAN and followed them for a median of 47 months (range 12–96 months). Serum galactose-deficient-IgA1 was measured at the time of diagnosis using a lectin-based ELISA and renal survival was modeled using the Cox proportional hazards method. The serum levels of galactose-deficient-IgA1 were higher in patients with IgAN compared to those in healthy controls. Importantly, in adjusted analysis, higher levels of galactose-deficient-IgA1 were independently associated with a greater risk of deterioration in renal function with a hazard ratio of 1.44 per standard deviation of the natural log-transformed galactose-deficient-IgA1 concentration. In reference to the first quartile, the risk of kidney failure increased such that the hazard ratio for the second quartile was 2.47, 3.86 for the third, and 4.76 for the fourth quartile of the galactose-deficient-IgA1 concentration. Hence, elevated serum levels of galactose-deficient-IgA1 are associated with a poor prognosis in IgAN.
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DOI：
10.1093/ndt/gfp273
发表时间：
2009-10
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Goto M;Wakai K;Kawamura T;Ando M;Endoh M;Tomino Y
通讯作者：
Tomino Y
影响因子：
13.2
作者：
Bartosik, LP;Lajoie, G;Cattran, DC
通讯作者：
Cattran, DC
影响因子：
13.2
作者：
Manno, Carlo;Strippoli, Giovanni F. M.;Schena, Francesco P.
通讯作者：
Schena, Francesco P.
影响因子：
19.6
作者：
通讯作者：
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影响因子：
19.6
作者：
Cattran, Daniel C.;Coppo, Rosanna;Zhang, Hong
通讯作者：
Zhang, Hong