A role for BDNF in mechanosensation
A role for BDNF in mechanosensation
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DOI：
10.1038/242
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发表时间：
1998-05-01
影响因子：
25
通讯作者：
Thoenen, H
中科院分区：
文献类型：
--
作者：
Carroll, P;Lewin, GR;Thoenen, H
脑源性神经营养因子（BDNF）是某些感觉神经元发育过程中的生存因子。通过对BDNF缺陷小鼠的电生理学研究，我们发现，在出生后，缓慢适应的机械感受器（SAM），而不是其他类型的皮肤传入神经，需要BDNF来实现正常的机械转导。缺乏BDNF的神经元没有死亡，而是表现出其机械敏感性的深刻和特异性降低，这在BDNF -/-和BDNF +/-动物中是相同的。产后用重组BDNF治疗BDNF +/-小鼠完全恢复了机械敏感性缺陷。因此，BDNF在调节SAM机械敏感性方面是重要的，独立于任何促进生存的功能。
Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction. Neurons lacking BDNF did not die, but instead showed a profound and specific reduction in their mechanical sensitivity, which was quantitatively the same in BDNF -/- and BDNF +/- animals. Postnatal treatment of BDNF +/- mice with recombinant BDNF completely rescued the mechanosensitivity deficit. Therefore BDNF is important for regulating SAM mechanosensitivity, independent of any survival-promoting function.