Neurocognitive and sociodemographic functioning of glioblastoma long-term survivors
Neurocognitive and sociodemographic functioning of glioblastoma long-term survivors
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DOI：
10.1007/s11060-012-0897-1
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发表时间：
2012-09-01
影响因子：
3.9
通讯作者：
Marosi, Christine
中科院分区：
文献类型：
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作者：
Flechl, Birgit;Ackerl, Michael;Marosi, Christine
越来越多的多形性胶质母细胞瘤患者在诊断后存活超过3年（长期存活者）。即便如此，人们对他们的日常表现和生活质量知之甚少。我们研究了17例存活超过3年的胶质母细胞瘤患者。我们使用计算机神经认知评估工具NeuroCog FX测试、EORTC QLQ-C30、EORTC QLQ-BN 20、医院焦虑和抑郁量表、十米步行测试、九孔桩测试、波士顿失语症严重程度量表以及日常生活活动和日常生活工具活动表评估所有患者。我们纳入了9名女性和8名男性胶质母细胞瘤长期存活者，中位年龄为51岁（24-71岁）。大多数患者（10/17）在NeuroCog FX测试中评分正常。然而，经常报告财务困难、社会和认知功能下降以及未来的不确定性。三名患者表现出明显的抑郁评分，两名患者表现出明显的焦虑结果。嗜睡和疲劳是最常报告的身体主诉。12/17例患者的日常生活活动完全独立，14例患者（82%）的Barthel指数显示千分之90分，但6例患者（35%）的手灵活性受损，1例患者的活动能力受损。胶质母细胞瘤长期存活者的认知功能表现出中度损害，更常见的是神经系统症状。然而，这些患者中的大多数能够独立管理他们的日常生活。然而，未来的前景仍然很差，病人遭受经济困难。
An increasing number of patients with glioblastoma multiforme live longer than 3 years after diagnosis (long-term survivors). Even so, little is known about their everyday performance and quality of life. We studied 17 glioblastoma patients surviving for longer than 3 years. We assessed all patients using the computerized neurocognitive assessment instrument NeuroCog FX test, the EORTC QLQ-C30, the EORTC QLQ-BN20, the Hospital Anxiety and Depression Scale, the Ten-Meter Walking Test, the Nine Hole Peg Test, the Boston Aphasia Severity Scale, and the Activities of Daily Living and Instrumental Activities of Daily Living forms. We included 9 female and 8 male glioblastoma long-term survivors with a median age of 51 years (24-71). The majority of the patients (10/17) scored normal in the NeuroCog FX test. However, financial difficulties, reduced social and cognitive functioning, and future uncertainty were frequently reported. Three patients showed conspicuous depression scores, two had noticeable anxiety results. Drowsiness and fatigue were the most often reported physical complaints. There were 12/17 patients who were fully independent concerning activities of daily living and 14 patients (82%) showed a parts per thousand yen90 points in the Barthel Index, but 6 patients (35%) were impaired in their manual dexterity, and 1 patient in mobility. Glioblastoma long-term survivors show moderate impairment in their cognitive functions and more often neurological symptoms. However, the majority of these patients are able to manage their daily routine independently. Nevertheless, future prospects remain poor and patients suffer from financial difficulties.