Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure.
Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure.
复制标题
慢性砷病患者的血管功能障碍可以通过减少砷暴露来逆转。
DOI：
10.1289/ehp.7471
复制
发表时间：
2005-03
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性砷暴露可引起与内源性一氧化氮系统性功能障碍相关的血管疾病。尽管砷中毒的可逆性尚未确定，但用低砷水替代严重砷污染的饮用水是砷中毒的一种潜在干预策略。本研究检测了内蒙古慢性砷中毒病区54例砷中毒患者饮用低砷水前后尿环鸟苷3′，5 ′-单磷酸（cGMP）（一氧化氮的血管活性作用的第二信使）的排泄及外周血管功能的体征和症状。砷中毒患者的尿cGMP排泄量显著减少（平均值± SEM：男性，37.0 ± 6.1;女性，37.2 ± 5.4 nmol/mmol肌酐），饮用低砷饮用水13个月后，这一趋势逆转（男性，68.0 ± 5.6;女性，70.6 ± 3.0 nmol/mmol肌酐），并改善了外周血管对冷应激的反应。我们的干预研究表明，砷中毒患者的外周血管疾病可以通过停止暴露来逆转，并对砷暴露的公共卫生方法具有重要意义。
Chronic arsenic exposure causes vascular diseases associated with systematic dysfunction of endogenous nitric oxide. Replacement of heavily arsenic-contaminated drinking water with low-arsenic water is a potential intervention strategy for arsenosis, although the reversibility of arsenic intoxication has not established. In the present study, we examined urinary excretion of cyclic guanosine 3′,5′-monophosphate (cGMP), a second messenger of the vasoactive effects of nitric oxide, and signs and symptoms for peripheral vascular function in 54 arsenosis patients before and after they were supplied with low-arsenic drinking water in an endemic area of chronic arsenic poisoning in Inner Mongolia, China. The arsenosis patients showed a marked decrease in urinary excretion of cGMP (mean ± SEM: male, 37.0 ± 6.1; female, 37.2 ± 5.4 nmol/mmol creatinine), and a 13-month period of consuming low-arsenic drinking water reversed this trend (male, 68.0 ± 5.6; female, 70.6 ± 3.0 nmol/mmol creatinine) and improved peripheral vascular response to cold stress. Our intervention study indicates that peripheral vascular disease in arsenosis patients can be reversed by exposure cessation and has important implications for the public health approach to arsenic exposure.