Sex and autoantibody titers determine the development of neuropsychiatric manifestations in lupus-prone mice
Sex and autoantibody titers determine the development of neuropsychiatric manifestations in lupus-prone mice
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DOI：
10.1016/j.jneuroim.2010.07.020
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发表时间：
2010-12-15
影响因子：
3.3
通讯作者：
Putterman, Chaim
中科院分区：
文献类型：
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作者：
Gao, Hua-Xin;Sanders, Elena;Putterman, Chaim
情绪障碍是SLE最常见的神经精神表现之一，SLE是一种女性占优势的全身性自身免疫性疾病。在这项研究中，我们评估了年轻的MRL/lpr小鼠，直接比较雄性和雌性。与MRL/lpr雄性动物相比，MRL/lpr雌性动物早在5周时就表现出显著的抑郁症（此时已存在自身抗体水平升高），而MRL/lpr雄性动物仅在18周时观察到抑郁症。抑郁症与抗核抗原，NMDA受体和核糖体P的自身抗体显着相关。我们的研究结果与自身抗体在狼疮模型早期神经精神缺陷发病机制中的主要作用一致，这转化为基于性别的临床表型差异。(C)2010 Elsevier B. V.保留所有权利。
Emotional disturbances are among the most common neuropsychiatric manifestations of SLE, a systemic autoimmune disease with a strong female predominance. In this study, we evaluated young MRL/lpr mice, directly comparing males and females. MRL/lpr females exhibited significant depression as early as 5 weeks (at which time elevated levels of autoantibodies were already present), as compared to MRL/lpr males, where depression was noted only at 18 weeks. Depression was significantly correlated with autoantibodies against nuclear antigens, NMDA receptor, and ribosomal P. Our results are consistent with a primary role of autoantibodies in the pathogenesis of early neuropsychiatric deficits in this lupus model, which translate into gender-based differences in clinical phenotype. (C) 2010 Elsevier B.V. All rights reserved.