Structural studies put phage defense mystery on the RADAR.
Structural studies put phage defense mystery on the RADAR.
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结构研究将噬菌体防御之谜置于雷达上。
DOI：
10.1016/j.cell.2023.02.003
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发表时间：
2023
期刊：
影响因子：
64.5
通讯作者：
MacRae,IanJ
中科院分区：
文献类型：
--
作者：
Wiryaman,Timothy;MacRae,IanJ
腺苷脱氨酶作用于 RNA (RADAR) 的噬菌体限制是细菌改变自身转录组以抵抗噬菌体的过程。在本期《细胞》中，邓肯-洛伊和塔尔等人。和高等人。两者都显示雷达蛋白组装成大量分子复合物，但对这些组装如何阻碍噬菌体提出了不同的观点。
Phage restriction by adenosine deaminase acting on RNA (RADAR) is a process by which bacteria may alter their own transcriptome to resist bacteriophage. In this issue ofCell, Duncan-Lowey and Tal et al. and Gao et al. both show RADAR proteins assemble into massive molecular complexes but present distinct views about how these assemblies obstruct phage.