A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B
A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B
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DOI：
10.1021/ja047826b
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发表时间：
2004-06-30
影响因子：
15
通讯作者：
Kishi, Y
中科院分区：
文献类型：
--
作者：
Namba, K;Jun, HS;Kishi, Y
一个简单的装置，包括两个离子交换柱，两个氧化铝过滤器，和一个泵（图1）组装，以形成C8−C14多环系统中存在的软海绵素B类海洋天然产品。该装置的有效性进行了测试，为三个基板。在每种情况下，所需的多环缩酮3，5，或7几乎定量获得在一个单一的操作。
A simple device consisting of two ion-exchange columns, two alumina-based filters, and a pump (Figure 1) was assembled to form the C8−C14 polycyclic ring system present in the halichondrin B class of marine natural products. The effectiveness of this device was tested for three substrates. In each case, the desired polycyclic ketal3,5, or7was obtained almost quantitatively in a single operation.