Copper-62-pyruvaldehyde bis(N4-methylthiosemicarbazone) PET imaging in the detection of coronary artery disease in humans
Copper-62-pyruvaldehyde bis(N4-methylthiosemicarbazone) PET imaging in the detection of coronary artery disease in humans
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DOI：
10.1067/mnc.2001.109929
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发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Stone, CK
中科院分区：
文献类型：
--
作者：
Wallhaus, TR;Lacy, J;Stone, CK
背景铜-62（II）-双乙醛缩二（N-4-甲基氨基硫脲）（PTSM）已被提议用于正电子发射断层扫描（PET）心脏显像。本研究评价了Cu-62-PTSM与冠状动脉造影在检测闭塞性冠状动脉疾病中的一致性。一组健康志愿者的Cu-62-PTSM PET的正常率也进行了评估。45例受试者完成了研究。28名患者接受了负荷锝-99mSestamibi单光子发射计算机断层扫描（SPECT）成像和心导管检查，随后进行Cu-62-PTSM静息/潘生丁负荷PET扫描，17名志愿者接受了Cu-62-PTSM静息/潘生丁负荷PET扫描。Cu-62-PTSM心肌灌注缺损在100%的3支血管病变患者（n = 8）、100%的2支血管病变患者（n = 9）和67%的单支血管病变患者（n = 6）中被确定。当考虑单个血管时，在左前降支、左回旋支和右冠状动脉区域分别有72%、67%和60%的闭塞性疾病患者中观察到Cu-62-PTSM灌注缺损。所有17名健康志愿者的Cu-62-PTSM扫描均被解释为正常，正常率为100%。通过Cu-62-PTSM PET在91%的心导管检查时观察到的闭塞性冠状动脉疾病患者中证实了灌注异常，并且其显示了100%的良好正常率。
Background. Copper-62 (II)-pyruvaldehyde bis(N-4-methyl-thiosemicarbazone) (PTSM) has been proposed for cardiac imaging with positron emission tomography (PET), This study evaluated the agreement between Cu-62-PTSM and coronary angiography in the detection of occlusive coronary artery disease. The normalcy rate for Cu-62-PTSM PET in a group of healthy volunteers was also assessed.Methods and Results. Forty-five subjects completed the study. Twenty-eight patients underwent stress technetium-99m sestamibi single photon emission computed tomography (SPECT) imaging and cardiac catheterization followed by Cu-62-PTSM rest/dipyridamole stress PET scans, and 17 volunteers underwent Cu-62-PTSM rest/dipyridamole stress PET scans. Cu-62-PTSM myocardial perfusion defects were identified in 100% of patients with 3-vessel disease (n = 8), 100% of patients with 2-vessel disease (n = 9), and 67% of patients,vith single-vessel disease (n = 6). When considering individual vessels, Cu-62-PTSM perfusion defects were seen in 72% of patients with occlusive disease in the left anterior descending artery territory, 67% in the left circumflex artery territory, and 60% in the right coronary artery territory, respectively All 17 healthy volunteers had Cu-62-PTSM scans interpreted as normal, for a normalcy rate of 100%.Conclusions. Perfusion abnormalities are demonstrated by means of Cu-62-PTSM PET in 91% of patients with occlusive coronary artery disease seen at the time of cardiac catheterization, and it shows an excellent normalcy rate of 100%.