PERSISTENCE OF INHIBITORY ACTIVITY AGAINST NORMAL BONE-MARROW CELLS DURING REMISSION OF ACUTE-LEUKEMIA
PERSISTENCE OF INHIBITORY ACTIVITY AGAINST NORMAL BONE-MARROW CELLS DURING REMISSION OF ACUTE-LEUKEMIA
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DOI：
10.1056/nejm197908163010702
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
MOORE, MAS
中科院分区：
文献类型：
--
作者：
BROXMEYER, HE;GROSSBARD, E;MOORE, MAS
对缓解期急性白血病患者的骨髓细胞产生一种物质(白血病相关抑制活性，LIA)的能力进行了测试，这种物质可以抑制正常(但不是白血病)骨髓培养中粒细胞和巨噬细胞集落的形成。83例缓解期患者中仅8例全骨髓提取液中检出LIA。从8例缓解期患者的全骨髓未产生LIA的骨髓中，用速度沉降法分离的慢沉细胞提取液全部产生抑制物质。从这些骨髓中提取的快速沉积的细胞含有LIA灭活剂。在6名未分离的骨髓对LIA无效的缓解期患者中，有3名患者的集落形成细胞亚群对抑制剂敏感。在急性白血病缓解期间，某些细胞功能显然不能完全恢复正常。
Bone marrow cells from patients with acute leukemia in remission were tested for capacity to produce a substance (leukemia-associated inhibitory activity, LIA) that inhibits formation of granulocyte and macrophage colonies in cultures of normal, but not leukemic, bone marrow. LIA was detected in extracts of whole marrow in only 8 of 83 patients in remission. Extracts of slowly sedimenting cells separated by velocity sedimentation from marrows of 8 patients in remission whose whole marrow had produced no LIA, produced inhibitory material in all cases. Extracts of more rapidly sedimenting cells from these marrows contained an LIA inactivator. Three of 6 patients in remission whose unfractionated marrow was unresponsive to LIA had a subpopulation of colony-forming cells that was sensitive to the inhibitor. Certain cellular functions apparently do not completely return to normal during remission of acute leukemia.