Changes in blood pressure and in vasoactive and volume regulatory hormones during semistarvation in obese subjects
Changes in blood pressure and in vasoactive and volume regulatory hormones during semistarvation in obese subjects
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DOI：
10.1016/s0026-0495(98)90245-1
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发表时间：
1998-05-01
影响因子：
9.8
通讯作者：
Kolanowski, J
中科院分区：
文献类型：
--
作者：
Messaoudi, L;Donckier, J;Kolanowski, J
研究人员对12名肥胖受试者进行了为期8天的严格限制能量饮食（1.67 MJ/d），每天摄入17毫摩尔钠的低热量饮食，以评估严格限制能量饮食降低血压的机制。观察大鼠血压、钠平衡、血浆容量、肾素醛固酮、交感神经系统活性、血浆心房钠素（ANF）原激素、脑钠素（BNP）、内皮素-1 （ET-1）浓度c端和n端变化的关系。整个饮食中存在负钠平衡，并与血浆容量的适度减少、肾素-醛固酮系统的显著激活以及伴随的c端和n端ANF原激素水平的降低有关。此外，在节食前记录的n端原ANF和ANF分泌的体位变化在节食8天后消失，与醛固酮和肾素的体位刺激相反。c端和n端ANF原激素水平与醛固酮水平呈负相关。尿儿茶酚胺排泄、BNP和ET-1保持不变。这些结果表明，在严格的热量限制期间发生的血压下降主要是由于有效血容量的减少，这反映在肾素-醛固酮系统的刺激和ANF水平的降低上。儿茶酚胺排泄和内皮素水平没有任何变化，表明在这些情况下外周血管阻力没有显著变化。版权所有(C) 1998由W.B. Saunders公司。
The mechanisms underlying the reduction in blood pressure that occurs with a severe energy-restricted diet were evaluated in 12 obese subjects during 8 days on a very-low-calorie diet (1.67 MJ/d) with a constant intake of 17 mmol sodium per day. The relationship between changes in blood pressure, sodium balance, plasma volume, renin-aldosterone and sympathetic nervous system activities, plasma C-terminus and N-terminus of the atrial natriuretic factor (ANF) prohormone, brain natriuretic peptide (BNP), and endothelin-1 (ET-1) concentrations was investigated. A negative sodium balance was present throughout the diet and was associated with a moderate reduction in plasma volume, a marked activation of the renin-aldosterone system, and a concomitant reduction in C-and N-terminal ANF prohormone levels. Moreover, the postural changes in N-terminal proANF and ANF secretion documented before the diet, disappeared after 8 days of dieting, in contrast to a greater postural stimulation of aldosterone and renin. A negative correlation was found between the changes of C-and N-terminal ANF prohormone levels and those of aldosterone. Urinary catecholamine excretion, BNP, and ET-1 remained unchanged. These results indicate that the decrease in blood pressure occurring during severe caloric restriction was essentially due to the reduction in the effective blood volume, as reflected by the stimulation of the renin-aldosterone system and the decrease in ANF levels. The lack of any changes in catecholamine excretion and endothelin levels suggests that peripheral vascular resistance did not change significantly in these circumstances. Copyright (C) 1998 by W.B. Saunders Company.