Absent prolactin (PRL) response to thyrotropin releasing hormone (TRH) and somatostatin (SRIF) in at term fetus
Absent prolactin (PRL) response to thyrotropin releasing hormone (TRH) and somatostatin (SRIF) in at term fetus
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足月胎儿催乳素 (PRL) 对促甲状腺素释放激素 (TRH) 和生长抑素 (SRIF) 反应缺失
DOI：
10.1007/bf03348461
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发表时间：
1984
影响因子：
5.4
通讯作者：
E. Roti
中科院分区：
文献类型：
--
作者：
G. Robuschi;L. d’Amato;M. Salvi;E. Gardini;M. Montermini;E. Dall’aglio;E. Borciani;V. Fontanesi;A. Alboni;A. Gnudi;E. Roti
为研究促甲状腺激素释放激素（TRH）和生长抑素（SRIF）对足月胎儿催乳素（PRL）分泌的影响，对足月孕妇在分娩过程中给予这些肽。有证据表明TRH和SRIF可以穿过胎盘屏障，影响垂体激素的分泌。37例孕妇口服TRH 400 μg。作为对照，11名妇女接受生理盐水。在母亲接受TRH的新生儿脐带血（CB）中，CB PRL浓度与盐水处理的新生儿没有差异，其值范围为192 ± 18和342 ± 48 ng/ml。55名女性在30分钟内输注500 μg生理盐水稀释的周期性SRIF。对照受试者输注生理盐水。出生时，SRIF治疗新生儿的CB PRL浓度范围为266 ± 32和327 ± 48 ng/ml。在母亲接受生理盐水治疗的新生儿中，CB PRL为305 ± 31 ng/ml。该值与SRI F处理组无显著差异。我们的研究结果表明，在足月胎儿TRH不刺激PRL分泌可能是因为胎儿垂体分泌PRL的最大释放活动。此外，SRIF给药对胎儿PRL分泌没有任何影响，这在成人中一直观察到。
To study the effect of thyrotropin-releasing hormone (TRH) and somatostatin (SRIF) on prolactin (PRL) secretion in at term human fetus these peptides have been administered to at term pregnant women during labor. Evidence has been reported that TRH and SRIF cross the placental barrier and affect the secretion of pituitary hormones. 400 μg TRH were administered to 37 pregnant women. As control 11 women received saline. In cord blood (CB) of neonates whose mothers received TRH CB PRL concentration was not different from those treated with saline, with values ranging between 192 ± 18 and 342 ± 48 ng/ml. 500 μg cyclic SRIF diluted in saline was infused over a period of 30 min in 55 women. Control subjects were infused with saline. At birth CB PRL concentration in SRIF treated neonates ranged between 266 ± 32 and 327 ± 48 ng/ml. In neonates whose mothers were treated with saline, CB PRL was 305 ± 31 ng/ml. This value was not significantly different from that in SRI F-treated groups. Our findings suggest that in at term human fetus TRH does not stimulate PRL secretion probably because fetal pituitary secretes PRL at maximal releasing activity. Furthermore SRIF administration does not have any effect on fetal PRL secretion as consistently observed in adults.
母体施用生长抑素后抑制胎儿生长激素（GH）和促甲状腺激素（TSH）的分泌。
DOI：
10.1530/acta.0.1060393
发表时间：
1984
期刊：
Acta endocrinologica
影响因子：
--
作者：
Roti,E;Robuschi,G;Alboni,A;Emanuele,R;d'Amato,L;Gardini,E;Salvi,M;Dall'Aglio,E;Gnudi,A;Braverman,LE
通讯作者：
Braverman,LE
胎儿时期生长激素对促甲状腺素释放激素的反应。
DOI：
10.1210/jcem-54-6-1255
发表时间：
1982
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Roti,E;Gnudi,A;Robuschi,G;Emanuele,R;Benassi,L;Braverman,LE
通讯作者：
Braverman,LE