Transmembrane signalling by interferon-alpha.
Transmembrane signalling by interferon-alpha.
复制标题
干扰素-α 的跨膜信号传导。
DOI：
10.1016/0163-7258(91)90005-7
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发表时间：
1991
影响因子：
13.5
通讯作者：
Colamonici,OR
中科院分区：
文献类型：
--
作者：
Pfeffer,LM;Colamonici,OR
人白细胞干扰素(α)与靶细胞上离散的细胞表面受体结合，从而改变基因表达。干扰素-α的跨膜信号涉及在不增加细胞内游离钙浓度的情况下产生DAG，以及随后激活不依赖钙的蛋白激酶C亚型(β和ϵ)。选择性蛋白激酶C抑制剂(H-7和星形孢子素)可以阻断干扰素-α激活一组不同的基因转录的能力，这些基因被称为干扰素刺激基因(Isg)，并保护细胞免受病毒感染。干扰素-α还可引起蛋白质磷酸化的快速变化，其中可能包括潜在的ISGs转录因子。
Human leukocyte interferon (IFN-α) binds to discrete cell surface receptors on target cells, and thereby alters gene expression. Transmembrane signaling by IFN-α involves the production of DAG without an increased intracellular free calcium concentration, and the subsequent activation of calcium-independent isoforms of PKC (β and ϵ). Selective PKC inhibitors (H-7 and staurosporine) can block the ability of IFN-α to activate the transcription of a distinct set of genes, called the IFN-stimulated genes (ISG), and to protect cells against viral infection. IFN-α also induces the rapid changes in protein phosphorylation, which may include latent transcription factors for ISGs.