HISTOCYTOLOGIC GRADING OF MUCOEPIDERMOID CARCINOMA OF MAJOR SALIVARY-GLANDS IN PROGNOSIS AND SURVIVAL - A CLINICOPATHOLOGICAL AND FLOW CYTOMETRIC INVESTIGATION
HISTOCYTOLOGIC GRADING OF MUCOEPIDERMOID CARCINOMA OF MAJOR SALIVARY-GLANDS IN PROGNOSIS AND SURVIVAL - A CLINICOPATHOLOGICAL AND FLOW CYTOMETRIC INVESTIGATION
复制标题
DOI：
10.1002/hed.2880170203
复制
发表时间：
1995-03-01
影响因子：
2.9
通讯作者：
BATSAKIS, JG
中科院分区：
文献类型：
--
作者：
HICKS, MJ;ELNAGGAR, AK;BATSAKIS, JG
背景关于涎腺粘液表皮样癌（MEG）的3层分级系统在预后和生存中的作用存在争议。本回顾性研究评估了Batsakis和Luna从Healey修改的3层分级系统，并比较了不同分级MEC的各种临床、病理和流式细胞术参数以及总生存率。研究了48例患者的腮腺（n = 43）和颌下腺（n = 5）的7例低度（LG）、23例中度（IG）和18例高度（HG）MEC。使用分类统计（Wilcoxon、Kruskal-Wallis和卡方检验，如适用）分析数据。LG肿瘤患者的平均年龄为42岁; IG为47岁; HG为59岁（p = 0.02）。性别比（p < 0.001）从LG（6只雌性：1只雄性）和IG（2.1只雌性：1只雄性）的女性优势变为HG（3.5只雄性：1只雌性）的男性优势。平均肿瘤分期为1.4 LG、2.4 IG和3.6 HG（p < 0.005）。肿瘤大小从LG的2.1 cm增加到HG的3.8 cm（p = 0.01）。在LG、IG和HG中，0%、44%和61%的肿瘤累及边缘（p < 0.001）。淋巴结受累率LG为0%，IG为22%，HG为72%（p < 0.001）。0% < 0.9 or >LG、13% IG和28% HG中存在DNA非整倍体（DNA指数1.1）（p = 0.05）。消化部分（S + G（2）M）为5% LG、7% IG和13% HG（p = 0.008）。14%的LG、35%的IG和61%的HG接受了放疗（p = 0.03）。复发（局部和/或转移性）发生在0%的LG、39%的IG和61%的HG中（p = 0.009）。生存率随肿瘤分级的增加而显著降低（p < 0.0001）（100%LG、IG和22%HG）。采用改良Healey三层系统，大涎腺粘液表皮样癌的组织学分级与影响患者预后和总生存率的临床、病理和流式细胞术因素密切相关。(C)1995年，John Wiley and Sons，Inc.
Background. Controversy exists regarding the role of a 3-tiered grading system for mucoepidermoid carcinoma (MEG) of salivary glands in prognosis and survival. This retrospective investigation evaluated a 3-tiered grading system modified from Healey by Batsakis and Luna and compared various clinical, pathologic, and flow cytometric parameters and overall survival among MECs of differing grades.Methods. Forty-eight patients with 7 low-grade (LG), 23 intermediate-grade (IG), and 18 high-grade (HG) MECs of parotid (n = 43) and submandibular (n = 5) glands were studied. Data were analyzed using categorical statistics (Wilcoxon, Kruskal-Wallis and Chi-squared tests where appropriate).Results. Mean ages were 42 years for patients with LG tumors; 47 years, IG; and 59 years, HG (p = 0.02). Gender ratio (p < 0.001) changed from female predominance in LG (6 F:1 M) and IG (2.1 F:1 M) to male predominance in HG (3.5 M:1 F). Mean tumor stage was 1.4 LG, 2.4 IG, and 3.6 HG (p < 0.005). Tumor size increased from 2.1 cm for LG to 3.8 cm for HG (p = 0.01). Margins were involved by tumor in 0% LG, 44% IG, and 61% HG (p < 0.001). Lymph node involvement was 0% LG, 22% IG, and 72% HG (p < 0.001). DNA aneuploidy (DNA index < 0.9 or > 1.1) was present in 0% LG, 13% IG, and 28% HG (p = 0.05). Proliferative fraction (S + G(2)M) was 5% LG, 7% IG, and 13% HG (p = 0.008). Radiotherapy was administered in 14% LG, 35% IG, and 61% HG (p = 0.03). Recurrences (local and/or metastatic) occurred in 0% LG, 39% IG, and 61% HG (p = 0.009). Survival was decreased significantly (p < 0.0001) with increasing tumor grade (100% LG, 70% IG, and 22% HG).Conclusion. Histologic grading of mucoepidermoid carcinomas of major salivary glands, using the modified Healey 3-tiered system, correlates well with clinical, pathologic, and flow cytometric factors which influence the prognosis and overall survival in affected individuals. (C) 1995 John Wiley and Sons, Inc.