Gender differences in pain modulation by a sweet stimulus in adults: A randomized study
Gender differences in pain modulation by a sweet stimulus in adults: A randomized study
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DOI：
10.1111/j.1442-2018.2010.00573.x
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发表时间：
2011-03-01
影响因子：
2.7
通讯作者：
Ishikawa, Toshizo
中科院分区：
文献类型：
--
作者：
Kakeda, Takahiro;Ishikawa, Toshizo
本研究的目的是探讨成年人中甜味刺激诱导的冷痛镇痛是否存在性别差异。在一项随机交叉设计中，20名男性和20名女性在将手浸入冷水之前或将24%的蔗糖溶液或蒸馏水含在口中，并检查其疼痛反应。与女性不同，当男性将蔗糖溶液含在嘴里时，与蒸馏水相比，疼痛发作的潜伏期显着增加。同时，男女的疼痛耐受水平没有显著差异。研究结果表明，甜味刺激对痛阈的镇痛作用受到成年人性别差异的影响，这表明甜味刺激诱导的镇痛作用短暂，特别是对男性。虽然还需要更多的研究，但这种甜蜜的刺激可以作为男性急性疼痛管理的辅助手段投入实际应用。
This study aimed to examine whether or not there are gender differences in sweet stimulus-induced analgesia for cold pain in adults. In a randomized cross-over design, twenty men and 20 women held either a 24% sucrose solution or distilled water in their mouth before and while they immersed their hand in cold water and their pain response was examined. Unlike the women, when the men held the sucrose solution in their mouth, the latency of the onset of pain significantly increased, compared with the distilled water. Meanwhile, the level of pain tolerance was not significantly different for both sexes. The findings reveal that the analgesic effect of a sweet stimulus on the pain threshold is influenced by gender differences in human adults, indicating that sweet stimulus-induced analgesia has a brief analgesic effect, particularly for men. Although more research is warranted, the sweet stimulus could be put to practical application as an adjunct to acute pain management for men.