Does Autoimmune Pancreatitis Increase the Risk of Pancreatic Carcinoma? A Retrospective Analysis of Pancreatic Resections
Does Autoimmune Pancreatitis Increase the Risk of Pancreatic Carcinoma? A Retrospective Analysis of Pancreatic Resections
复制标题
DOI：
10.1097/mpa.0b013e31826bef91
复制
发表时间：
2013-04-01
期刊：
影响因子：
2.9
通讯作者：
Deshpande, Vikram
中科院分区：
文献类型：
--
作者：
Gupta, Rajib;Khosroshahi, Arezou;Deshpande, Vikram
目的：方法：对28例自身免疫性胰腺炎（AIP）和30例慢性胰腺炎（CP-NOS）进行胰腺上皮内瘤样病变（PanIN）的检测，比较两者的发生率。结果：AIP组的平均年龄（57岁）显著高于CP-NOS组（47岁）（P = 0.01）。23例（82%）AIP显示PanIN，7例（25%）显示2级PanIN。在1例AIP病例中确定了3级PanIN。与2型AIP相比，1型AIP的高级别PanIN病变病例数无统计学显著差异。与CP-NOS相比，患有PanIN（82%的AIP病例vs 63%的CP-NOS病例）（P = NS）和PanIN 2（25%的AIP vs 20%的CP-NOS）（P = NS）的AIP患者百分比相当。在我们的机构（平均随访，49个月）的84例AIP，2例胰腺癌被确定为6和10年后的诊断AIP.Conclusions：这些研究结果引起关注，AIP与恶性肿瘤的风险升高，并应提示更多的研究。
Objectives: To estimate the risk of malignancy in autoimmune pancreatitis (AIP).Methods: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and 30 cases of chronic pancreatitis not otherwise specified (CP-NOS). We also reviewed a cohort of 84 AIP cases.Results: The mean age of the AIP cohort (57 years) was significantly higher than that of the cohort of CP-NOS (47 years) (P = 0.01). Twenty-three cases (82%) of AIP showed PanIN, and 7 cases (25%) showed grade 2 PanIN. Grade 3 PanIN was identified in one case of AIP. There was no statistically significant difference in the number of cases with high-grade PanIN lesions between the cases of type 1 as opposed to type 2 AIP. In comparison to CP-NOS, a comparable percentage of patients with AIP had PanIN (82% of AIP cases vs 63% of CP-NOS cases) (P = NS) and PanIN 2 (25% AIP vs 20% CP-NOS) (P = NS). Of the 84 AIP cases at our institution (mean follow-up, 49 months), 2 cases of pancreatic carcinoma were identified 6 and 10 years after the diagnoses of AIP.Conclusions: These findings raise concern that AIP is associated with an elevated risk of malignancy and should prompt additional studies.